Synthesis and properties of zirconium(IV) and molybdate(II) morin complexes

Panhwar, Qadeer Khan; Memon, Shahabuddin

doi:10.1080/00958972.2012.668617

Cited by 20 publications

(9 citation statements)

References 33 publications

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“… 45 The electronic transition within morin shifts from n−Π* to lower energy Π–Π* favoring the development of a new band at higher wavelength. 46 , 47 The binding constant of the Morin–Pb 2+ complex was found to be 1.803 × 10 4 M –1 ( R 2 = 0.987) using the Benesi–Hildebrand equation 48 where, A 0 , A , and A f are the absorption values, in the absence of, at the intermediate, and at the saturation of the interaction of Pb 2+ ion, respectively, and [Pb 2+ ] represents the concentration of aqueous Pb 2+ ion added. The binding constant ( K b ) was determined by linear fitting of absorption titration curve ( Figure S1 ).…”

Section: Resultsmentioning

confidence: 99%

Spectroscopic Studies on Dual Role of Natural Flavonoids in Detoxification of Lead Poisoning: Bench-to-Bedside Preclinical Trial

Adhikari

Darbar²,

Chatterjee

et al. 2018

ACS Omega

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Ubiquitousness in the target organs and associated oxidative stress are the most common manifestations of heavy-metal poisoning in living bodies. While chelation of toxic heavy metals is important as therapeutic strategy, scavenging of increased reactive oxygen species, reactive nitrogen species and free radicals are equally important. Here, we have studied the lead (Pb) chelating efficacy of a model flavonoid morin using steady-state and picosecond-resolved optical spectroscopy. The efficacy of morin in presence of other flavonoid (naringin) and polyphenol (ellagic acid) leading to synergistic combination has also been confirmed from the spectroscopic studies. Our studies further reveal that antioxidant activity (2,2-diphenyl-1-picrylhydrazyl assay) of the Pb–morin complex is sustainable compared to that of Pb-free morin. The metal–morin chelate is also found to be significantly soluble compared to that of morin in aqueous media. Heavy-metal chelation and sustainable antioxidant activity of the soluble chelate complex are found to accelerate the Pb-detoxification in the chemical bench (in vitro). Considering the synergistic effect of flavonoids in Pb-detoxification and their omnipresence in medicinal plants, we have prepared a mixture (SKP17LIV01) of flavonoids and polyphenols of plant origin. The mixture has been characterized using high-resolution liquid chromatography assisted mass spectrometry. The mixture (SKP17LIV01) containing 34 flavonoids and 76 other polyphenols have been used to investigate the Pb detoxification in mouse model. The biochemical and histopathological studies on the mouse model confirm the dual action in preclinical studies.

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Section: Resultsmentioning

confidence: 99%

Spectroscopic Studies on Dual Role of Natural Flavonoids in Detoxification of Lead Poisoning: Bench-to-Bedside Preclinical Trial

Adhikari

Darbar²,

Chatterjee

et al. 2018

ACS Omega

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“…Therefore, it becomes comprehensible that metal ion replaces the 5-OH proton that leads to the destruction of hydrogen bonds after chelation and morin acts as monobasic bidentate ligand. Therefore, 1 H-NMR study provides very important information regarding the complex structure that 5-OH group is main site which is involved in complex formation in conjunction with 4C=O, indicating that the whole molecule retains the planar structure of the natural morin [ 30 , 31 ]. A broad signal appeared at 3.45 ppm value represents the presence of water molecules in the complex structure [ 32 ].…”

Section: Resultsmentioning

confidence: 99%

Synthesis of Cr(III)-Morin Complex: Characterization and Antioxidant Study

Panhwar

Memon

2014

The Scientific World Journal

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The complex formation between Cr(III) and morin was carried out in methanol and confirmed by analytical characterization using UV-Vis, IR, 1H NMR, and TG-DTA. UV-Vis shows significant bathochromic shift in benzoyl upon coordination as well as IR well illustrates the peak shift of C=O group and formation of a O–Cr(III) bond. Likewise, 1H NMR studies clarify that Cr(III) metal ion replaces the 5OH proton hence; 5-hydroxy-4-keto site is employed by morin in chelation to form six-membered stable ring system out of three available chelating sites. In addition, TG-DTA denotes the presence of coordinated and crystalline water molecules. The melting point of the complex was found to be 389°C by DSC. In addition, Cr(III)-morin complex was found to be a more potent antioxidant than morin as evaluated by DPPH• and FRAP methods.

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“…Because plant extracts are abundant in phenolic compounds (and the concentration of phenolic compounds is a decisive parameter of the antioxidant activity of extract) the interactions of phenolic-metal ion may influence the antioxidant activity of sample. Some papers postulated that the presence of metal ions may increase the antioxidant activity of phenolic compounds because metal coordination change the redox potential of ligand and increase in the electron-donating ability of phenolics 52 – 54 . However, there are other studies which revealed that the antioxidant properties of phenolic compounds decreased upon complexation 51 , 53 , 55 or the oxidant activity changed from anti- to pro-oxidant when the lifetime of phenoxyl radicals is prolonged due to spin-stabilizing effect induced by metal cations 56 .…”

Section: Discussionmentioning

confidence: 99%

Phenolic content, chemical composition and anti-/pro-oxidant activity of Gold Milenium and Papierowka apple peel extracts

Kalinowska

Gryko

Wróblewska

et al. 2020

Sci Rep

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In this study the peels of ecologically grown apple (Malus domestica) cultivars: Gold Milenium (a new scab‐resistant variety) and Papierowka (Papirovka; an old, sensitive to apple scab variety) were examined for their composition (phenolic compounds, triterpenoids, simple organic acids, macro-, microelements, reducing sugars, l-ascorbic acid), pro- and antioxidant properties as well as their application in reduction of the oxidative stress in cultured human skin fibroblast. The higher content of phenolic compounds correlated with the greater pro- and antioxidant activity of the peels of Papierowka compared to Gold Milenium in DPPH·, ABTS+, FRAP and CUPRAC assays as well as an ability to inhibition of lipid peroxidation. The quantity of the compounds strongly depended on the type of extraction. The extract of Papierowka peels possessed much higher amount of phenolic compounds compared to Gold Milenium (Papierowka: 3.68 ± 0.20 mg/g peel ultrasound assisted extraction (u.a.e); 2.02 ± 0.13 mg/g peel conventional extraction (c.e.); Gold Milenium: 1.46 ± 0.19 mg/g peel u.a.e; 1.15 ± 0.04 mg/g peel c.e. according the HPLC measurement). The pro-oxidant activity of the extract from Papierowka peels can be correlated with the content of phenolic compounds and metal ions as well. The apple peel extract is promising agent reducing the oxidative stress in skin fibroblast.

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Synthesis and properties of zirconium(IV) and molybdate(II) morin complexes

Cited by 20 publications

References 33 publications

Spectroscopic Studies on Dual Role of Natural Flavonoids in Detoxification of Lead Poisoning: Bench-to-Bedside Preclinical Trial

Spectroscopic Studies on Dual Role of Natural Flavonoids in Detoxification of Lead Poisoning: Bench-to-Bedside Preclinical Trial

Synthesis of Cr(III)-Morin Complex: Characterization and Antioxidant Study

Phenolic content, chemical composition and anti-/pro-oxidant activity of Gold Milenium and Papierowka apple peel extracts

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