“…The mass spectrum of the same compound showed two isotopic molecular ion peaks at m/z 297 and 299 which is in agreement with its molecular formula. In addition, the mass spectra of the chalcone derivatives IIb-f exhibited the molecular ion peaks of the compounds confirming their structural formulae These chalcones are considered to be useful intermediates in several cyclization reactions to produce different types of heterocyclic compounds according to the used reactants and the reaction's conditions 40,41 . Thus, in the present investigation, the target quinazolines IIIa,b, VIa,b and Va,b were obtained by condensation of the prepared chalcones IIa,b with urea , thiourea and guanidine salt respectively in refluxing ethanol under alkaline medium conditions.…”
Objectives: The notable advancing in the medicinal chemistry arena against infectious diseases has resulted in the discovery of numerous valuable antimicrobial drugs that saved millions of lives throughout the last few decades. Nevertheless, the continuous reporting of multi-drug resistant strains of a number of diverse germs makes the need for novel broad-spectrum anti-infective agents still exists. Methods: Three series of ring-equivalent tricyclic benzo The antimicrobial activity of some of the synthesized compounds was screened and only 2-bromo derivative IX and aminothiazole compound X exhibited broad antimicrobial effectiveness. The antifungal MIC value of X was1.85 mg/mL.
Conclusion:The new synthesized compounds, designed as bioisosteres, showed excellent potency against the tested gram (+) bacterial and fungal strains compared to reference drugs.
“…The mass spectrum of the same compound showed two isotopic molecular ion peaks at m/z 297 and 299 which is in agreement with its molecular formula. In addition, the mass spectra of the chalcone derivatives IIb-f exhibited the molecular ion peaks of the compounds confirming their structural formulae These chalcones are considered to be useful intermediates in several cyclization reactions to produce different types of heterocyclic compounds according to the used reactants and the reaction's conditions 40,41 . Thus, in the present investigation, the target quinazolines IIIa,b, VIa,b and Va,b were obtained by condensation of the prepared chalcones IIa,b with urea , thiourea and guanidine salt respectively in refluxing ethanol under alkaline medium conditions.…”
Objectives: The notable advancing in the medicinal chemistry arena against infectious diseases has resulted in the discovery of numerous valuable antimicrobial drugs that saved millions of lives throughout the last few decades. Nevertheless, the continuous reporting of multi-drug resistant strains of a number of diverse germs makes the need for novel broad-spectrum anti-infective agents still exists. Methods: Three series of ring-equivalent tricyclic benzo The antimicrobial activity of some of the synthesized compounds was screened and only 2-bromo derivative IX and aminothiazole compound X exhibited broad antimicrobial effectiveness. The antifungal MIC value of X was1.85 mg/mL.
Conclusion:The new synthesized compounds, designed as bioisosteres, showed excellent potency against the tested gram (+) bacterial and fungal strains compared to reference drugs.
“…Water used for total procedures was deionized. [1,4]oxazine 3 was prepared from 1,3,3-trimethyl-2-methyleneindoline 1 and 1-nitroso-2,7-dihydroxynaphthalene 2 according to the method described in Refs [9,10] …”
Section: Experimental Materialsmentioning
confidence: 99%
“…In recent years, photochromic and thermochromic spiropyrans and spirooxazines have been receiving considerable attention, due to their potential application in many new technologies, such as data recording and storage, optical switching, displays, and non-linear optics [3,4]. For examples, the synthesis of cationic spiroxazine and alternate multilayer films of cationic spiroxazine and anionic polystyrenesulfonate (PSS) were prepared by layer-by-layer deposition using electrostatic attraction between oppositely charged ions.…”
Photochromic poly(methyl methacrylate) (PMMA)/spirooxazine microspheres were prepared by in situ suspension polymerization and those photochromic behaviors were investigated. When UV irradiation was subjected to the PMMA/ spirooxazine microspheres, the reflection spectra generated by photochromic reaction was clearly observed and its reversible decoloration behaviors responded rapidly in the dark. Photochromic microspheres prepared in this work, could be used to photochromic fabrics such as microcapsules for fragrant finishing of fabrics, as well as those are could be applied in sensing materials.
“…Photochromism studies of spirooxazine in polymer matrices [17], liquid crystal polymers containing spirooxazine as mesophases [18], spirooxazine grafted, poly[2-ethynyl-pyridinum bromide] ionic conjugated polymer [19], poly[N,N- [20] and other synthetic polymers [21,22] have recently been developed. However, photocontrollable fluorescent changes of spirooxazine are very scarce [23]; in particular, photoswitchable fluorescent photochromic spirooxazine polymers are virtually unknown.…”
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