Synthesis and Properties of Polyanhydrides Containing Urethane Bonds in the Main Chain†

Engineering bioerodible polymers with tailored micro/nanostructure for vaccine delivery

“…Table 2.9 shows the degradation rate of a representative poly(anhydride-co-urethane), a poly(anhydride-co-amide), and a poly(anhydride-co-ester) of different molecular weights (Hartmann et al, 1993). For all of these polymers, the reported erosion rate decreases as the molecular weight increases.…”

“…8400 3600 2160 9120 5280 2880 480 5900 9100 13,700 6800 10,800 6,390 10,900 (Hartmann et al, 1993) (Hartmann et al, 1993) (Hartmann et al, 1993) "Erosion experiment conducted at pH 7.2 ^Estimated from linear portion of sigmoidal profile example Shakesheff et al, 1994) that crystalline domains erode much more slowly than amorphous domains. Thus, careful control of crystallinity may be necessary to accurately modulate erosion and drug release kinetics.…”

“…s. In their investigation of polyanhydrides with novel chemistries, Hartmann et al (1993) synthesized several poly(anhydride-courethane)s and compared their degradation kinetics to the poly(anhydride-co-ester)s and poly(anhydride-co-amide)s with similar structures. Poly(anhydride-co-amide)s, and poly(anhydride-co-urethane)s degraded by hydrolysis of the anhydride bond only, but poly(anhydride-co-ester)s degraded at both the ester and the anhydride bond.…”