Synthesis and Properties of Phosphorus-Containing Pseudo-Poly(Amino Acid)sof Polyester Type Based on N-Derivatives of Glutaminic Acid

Abstract

Poly(phosphoeter)s (PPE)s are a class of polymers possessing a high chemical functionality and biodegradability. Novel, glutamic acid based poly(phosphoeter)s were synthesized by the Steglich reaction. The developed synthetic approach allows controlling the composition and the structure of PPEs, and therefore their physical and colloidal properties. The studies on solubilization and cytotoxicity in vitro proved the potential of PPEs for drug delivery applications.

Polyphosphate Ester-Type Transporters Improve Antimicrobial Properties of Oxytetracycline

“…The obtained molecule contains lipophilic and hydrophilic fragments, which exhibit amphiphilic properties. It has surfactant properties and the ability to form self-stabilized dispersions with a nanometric dispersed phase in aqueous and physiological solutions [ 25 , 26 ]. The presence of a phosphate group (in the hydrophilic fragment after hydrolysis of the ethoxy group) provides conjugates with molecules that exhibit base properties [ 19 ].…”

“…As shown in the results, newly created transporters of the polyphosphate ester type were able to bind and solubilize oxytetracycline. Studies have shown that polymers based on pseudo-polyamino acids, which are similar to polyphosphate ester-type nano transporters, penetrate cells and mitochondria [ 27 , 28 , 29 ]. Low-charged and amphiphilic properties facilitate membrane penetration by these compounds [ 30 , 31 ].…”

“…To determine the sensitivities of microorganisms to the antibiotic on solid media, oxytetracycline hydrochloride and its complexes with polyphosphate ester-type (P4 and P6) were applied to paper disks (d = 10 mm) in the following doses: 2.3, 2.9, 3.8, and 5.4 μg/disk for S. aureus ; and 8, 11, 14, and 20 μg/disk for E. coli and P. aeruginosa as previously described [ 26 ]. All experiments were performed in seven repetitions.…”