Synthesis and properties of new trinuclear Mo(II) complexes containing imidazole and benzimidazole ferrocene units

Mo(II) complexes: A new family of cytotoxic agents?

“…The stock solution of ct DNA gave a ratio of UV absorbance at 260 and 280 nm (A 260 /A 280 ) of 1.87, indicating that the DNA was sufficiently free of protein contamination. The DNA concentration was determined by the UV absorbance at 260 nm after 1:10 dilution using ε = 6600 M − 1 cm − 1 [23]. MTT was dissolved (5 mg/mL) in phosphate buffer saline pH 7.2.…”

“…We reported in an earlier work the antitumor activity of Mo(II) complexes associated with ferrocene, but the results were disappointing [23], even though the ferricinium ion by itself and other derivatives display some activity [24]. On the other hand, complexes [Mo(η 3 -C 3 H 5 )X(CO) 2 (N-N)], with X = Br, CF 3 SO 3 and N-N = 2-(2′-pyridyl)benzimidazole) or 2-(2′-pyridyl)imidazole) exhibited a high activity against several cell lines [25].…”

Synthesis and properties of new Mo(II) complexes with N-heterocyclic and ferrocenyl ligands

“…At low temperatures the signals could be resolved and revealed the presence of three isomers, C1a-A, C1a-B and C1a-C in the 2:1:1 ratio, with C1a-B and C1a-C in chemical exchange. The NOESY spectrum does not allow us to group the dpa, allyl and CH 3 CN resonances for the isomers C1a-B and C1a-C. (11) 77.7(2) N(100)eMoeN (11) 83.5(2) C(100)eMoeN (11) 95.6(2) C(200)eMoeN (11) 162.9(2) C(100)eMoeC ( (11) 98.8(6) C(300)eMo(2)eN (31) 173.5(7) C(100)eMo(1)eN (23) 169.7(7) C(300)eMo(2)eN(43) 97.8(7) C(100)eMo (1)eN(51) 85.7(6) C(400)eMo(2)eN (31) 98.2(7) C(200)eMo (1)eN(51) 85.2(7) C(300)eMo(2)eN(61) 87.8(7) C(200)eMo(1)eN (11) 168.1(7) C(400)eMo(2)eN (43) 169.6(7) C(200)eMo(1)eN (23) 93.3(8) C(400)eMo (2) The isomer present in larger amounts should be the E one, as observed in the crystal structure (see above), the other two being assigned to the A and A* isomers (Scheme 2), as has been described in detail for complex C1 [13] and others [14,15].…”

“…Functionalized ferrocenes can be used as ligands in reactions with other metal fragments, opening a way into the synthesis of polymetallic species [6] with new structures and properties [7], such as in sensors [8], and even polymers [9]. In previous work we reported the coordination of ferrocenyl based nitrogen ligands, namely FcCO(NH 2 benzim), (FcCO) 2 (NHbenzim) [10], FcCO(im) and FcCO(benzim) [11] (benzim ¼ benzimidazole and im ¼ imidazole) to the Mo(II) fragment MoBr(h 3 -C 3 H 5 )(CO) 2 . The new bi-and tri-nuclear complexes thus obtained showed interesting redox properties, namely a switch in the nature of highest energy electron, which occupied a molybdenum level instead of an iron level.…”

“…The new bi-and tri-nuclear complexes thus obtained showed interesting redox properties, namely a switch in the nature of highest energy electron, which occupied a molybdenum level instead of an iron level. The association of Fe and Mo was also studied in order to improve cytotoxic activity relative to that of the isolated components [11]. In the present work, we explore structural alternatives of [MoBr(h 3 -C 3 H 5 )(CO) 2 (L-L)] and its cationic derivatives [Mo (h 3 -C 3 H 5 )(CO) 2 (L-L)(NCMe)] þ , where L-L ¼ 2,2 0 -dipyridylamine ligand (L1), L2 ¼ {[bis(2-pyridyl)amino]carbonyl}ferrocene, and L3 ¼ N,Nbis(ferrocenecarbonyl)-2-aminopyridine (see Scheme 1).…”