Synthesis and Properties of Chitosan- and Pectin-Based Hydrogels

Sigaeva, N. N.; Vil’danova, R. R.; Султанбаев, А. В.; Ivanov, S. P.

doi:10.1134/s1061933x20030114

Cited by 6 publications

(3 citation statements)

References 15 publications

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“…In another study, Ch-Pec hydrogels, despite a rapid swelling (in about 15 min), reached a swelling ratio value of 370% (Birch et al, 2015), while another system showed a swelling value of 150-200% in about 1 h, thus significantly lower and in a longer time than our formulations (Bernabé et al, 2005). Other studies reported even longer times to reach maximum swelling (Michailidou et al, 2021;Neufeld & Bianco-Peled, 2017;Shitrit et al, 2019;Sigaeva et al, 2020). Swelling ratio values similar to our systems are rarely found in Ch-Pec hydrogels: e.g.…”

Section: Discussioncontrasting

confidence: 40%

A thermo-sensitive chitosan/pectin hydrogel for long-term tumor spheroid culture

Morello

Quarta

Gaballo

et al. 2021

Carbohydrate Polymers

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Section: Discussioncontrasting

confidence: 40%

A thermo-sensitive chitosan/pectin hydrogel for long-term tumor spheroid culture

Morello

Quarta

Gaballo

et al. 2021

Carbohydrate Polymers

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“…The three hydrogels reached very fast (less than 30 min) and very high swelling values (between 1500 and 2000%) in both formulations with and without DMEM, faster and higher values than similar Ch-Pe systems proposed by other authors that reported lower swelling ratio values (about 370% [ 27 ], 150–200% [ 40 ] or slower [ 15 ]) [ 14 , 29 , 31 , 41 ]. Regarding the in vitro stability, tested up to 25 days, hydrogels without DMEM were stable up to 25 days, except for the Ch-Pec-PB samples that completely degraded after 7 days.…”

Section: Discussionmentioning

confidence: 51%

Preparation and Characterization of Salt-Mediated Injectable Thermosensitive Chitosan/Pectin Hydrogels for Cell Embedding and Culturing

et al. 2021

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In recent years, growing attention has been directed to the development of 3D in vitro tissue models for the study of the physiopathological mechanisms behind organ functioning and diseases. Hydrogels, acting as 3D supporting architectures, allow cells to organize spatially more closely to what they physiologically experience in vivo. In this scenario, natural polymer hybrid hydrogels display marked biocompatibility and versatility, representing valid biomaterials for 3D in vitro studies. Here, thermosensitive injectable hydrogels constituted by chitosan and pectin were designed. We exploited the feature of chitosan to thermally undergo sol–gel transition upon the addition of salts, forming a compound that incorporates pectin into a semi-interpenetrating polymer network (semi-IPN). Three salt solutions were tested, namely, beta-glycerophosphate (βGP), phosphate buffer (PB) and sodium hydrogen carbonate (SHC). The hydrogel formulations (i) were injectable at room temperature, (ii) gelled at 37 °C and (iii) presented a physiological pH, suitable for cell encapsulation. Hydrogels were stable in culture conditions, were able to retain a high water amount and displayed an open and highly interconnected porosity and suitable mechanical properties, with Young’s modulus values in the range of soft biological tissues. The developed chitosan/pectin system can be successfully used as a 3D in vitro platform for studying tissue physiopathology.

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“…The addition of cisplatin to hydrogels has practically no effect on their properties; at the same time, there is a slight decrease in the gelation time, probably due to additional physical interactions between the polymers and the drug. Thus, it was shown in [ 31 ] that the amino groups of cisplatin interact with the carboxyl groups of pectin.…”

Section: Resultsmentioning

confidence: 99%

Biodegradable Hydrogels Based on Chitosan and Pectin for Cisplatin Delivery

Vil’danova

Петрова

Колесов

et al. 2023

Gels

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Preparation of stable hydrogels using physically (electrostatically) interacting charge-complementary polyelectrolyte chains seems to be more attractive from a practical point of view than the use of organic crosslinking agents. In this work natural polyelectrolytes—chitosan and pectin—were used, due to their biocompatibility and biodegradability. The biodegradability of hydrogels is confirmed by experiments with hyaluronidase as an enzyme. It has been shown that the use of pectins with different molecular weights makes it possible to prepare hydrogels with different rheological characteristics and swelling kinetics. These polyelectrolyte hydrogels loaded with cytostatic cisplatin as a model drug provide an opportunity for its prolonged release, which is important for therapy. The drug release is regulated to a certain extent by the choice of hydrogel composition. The developed systems can potentially improve the effects of cancer treatment due to the prolonged release of cytostatic cisplatin.

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Synthesis and Properties of Chitosan- and Pectin-Based Hydrogels

Cited by 6 publications

References 15 publications

A thermo-sensitive chitosan/pectin hydrogel for long-term tumor spheroid culture

A thermo-sensitive chitosan/pectin hydrogel for long-term tumor spheroid culture

Preparation and Characterization of Salt-Mediated Injectable Thermosensitive Chitosan/Pectin Hydrogels for Cell Embedding and Culturing

Biodegradable Hydrogels Based on Chitosan and Pectin for Cisplatin Delivery

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