Biodegradable Hydrogels Based on Chitosan and Pectin for Cisplatin Delivery

Vil’danova, R. R.; Петрова, С. Ф.; Колесов, С. В.; Khutoryanskiy, Vitaliy V.

doi:10.3390/gels9040342

Cited by 6 publications

(4 citation statements)

References 33 publications

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“…UV-Vis spectroscopy [70] and high-performance liquid chromatography (HPLC) monitor the concentration of released substances over time. These data are crucial for designing hydrogel-based drug delivery systems with controlled and sustained release profiles [71].…”

Section: Methodsmentioning

confidence: 99%

Exploring the Potential of Artificial Intelligence for Hydrogel Development—A Short Review

Negut,

Bita

2023

Gels

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AI and ML have emerged as transformative tools in various scientific domains, including hydrogel design. This work explores the integration of AI and ML techniques in the realm of hydrogel development, highlighting their significance in enhancing the design, characterisation, and optimisation of hydrogels for diverse applications. We introduced the concept of AI train hydrogel design, underscoring its potential to decode intricate relationships between hydrogel compositions, structures, and properties from complex data sets. In this work, we outlined classical physical and chemical techniques in hydrogel design, setting the stage for AI/ML advancements. These methods provide a foundational understanding for the subsequent AI-driven innovations. Numerical and analytical methods empowered by AI/ML were also included. These computational tools enable predictive simulations of hydrogel behaviour under varying conditions, aiding in property customisation. We also emphasised AI’s impact, elucidating its role in rapid material discovery, precise property predictions, and optimal design. ML techniques like neural networks and support vector machines that expedite pattern recognition and predictive modelling using vast datasets, advancing hydrogel formulation discovery are also presented. AI and ML’s have a transformative influence on hydrogel design. AI and ML have revolutionised hydrogel design by expediting material discovery, optimising properties, reducing costs, and enabling precise customisation. These technologies have the potential to address pressing healthcare and biomedical challenges, offering innovative solutions for drug delivery, tissue engineering, wound healing, and more. By harmonising computational insights with classical techniques, researchers can unlock unprecedented hydrogel potentials, tailoring solutions for diverse applications.

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Section: Methodsmentioning

confidence: 99%

Exploring the Potential of Artificial Intelligence for Hydrogel Development—A Short Review

Negut,

Bita

2023

Gels

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“…However, it is essential to note that certain crosslinkers used in the chemical crosslinking process may have reported toxicity, requiring their extraction from the hydrogel before use to ensure safety. Physically crosslinked hydrogels, on the other hand, rely on non-covalent interactions, such as ionic contracts, hydrogen bonds, or hydrophobic interactions, to stop the dissolution of the polymer chains and keep the hydrogel structure stable [32]. Physically crosslinked hydrogels offer an alternative solution to address crosslinker toxicity concerns, as the interactions can be reversibly formed and disrupted, allowing for potential recycling or reprocessing of the hydrogel [33].…”

Section: Molecular Structure Of Hydrogelsmentioning

confidence: 99%

Chitosan-Based Hydrogel in the Management of Dermal Infections: A Review

Mohite,

Rahayu,

Munde

et al. 2023

Gels

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The main objective of this review is to provide a comprehensive overview of the current evidence regarding the use of chitosan-based hydrogels to manage skin infections. Chitosan, a naturally occurring polysaccharide derived from chitin, possesses inherent antimicrobial properties, making it a promising candidate for treating various dermal infections. This review follows a systematic approach to analyze relevant studies that have investigated the effectiveness of chitosan-based hydrogels in the context of dermal infections. By examining the available evidence, this review aims to evaluate these hydrogels’ overall efficacy, safety, and potential applications for managing dermal infections. This review’s primary focus is to gather and analyze data from different recent studies about chitosan-based hydrogels combating dermal infections; this includes assessing their ability to inhibit the growth of microorganisms and reduce infection-related symptoms. Furthermore, this review also considers the safety profile of chitosan-based hydrogels, examining any potential adverse effects associated with their use. This evaluation is crucial to ensure that these hydrogels can be safely utilized in the management of dermal infections without causing harm to patients. The review aims to provide healthcare professionals and researchers with a comprehensive understanding of the current evidence regarding the use of chitosan-based hydrogels for dermal infection management. The findings from this review can contribute to informed decision-making and the development of potential treatment strategies in this field.

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“…Biodegradable gels based on pectin and chitosan were obtained by a group under Khutoryanskiy; the rheological properties, swelling ability of gels, degradation under the action of hyaluronidase as an enzyme, and release of cisplatin were studied as well [13]. It has been shown that the use of pectins with different molecular weights makes it possible to prepare hydrogels with different rheological characteristics and swelling kinetics.…”

Section: Of 19mentioning

confidence: 99%

Characteristics of Interpolyelectrolyte Complexes Based on Different Types of Pectin with Eudragit® EPO as Novel Carriers for Colon-Specific Drug Delivery

Nasibullin,

Dunaeva,

Akramova

et al. 2023

IJMS

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Given that pectin is a well-known substance used for drug delivery, we aimed to obtain and further examine the efficacy of interpolyelectrolyte complexes based on citrus or apple pectin and the Eudragit® EPO for using these carriers in oral drug delivery. To characterize the physicochemical properties of these compounds, turbidity, gravimetry, viscosity, elementary analysis, FTIR spectroscopy, and DSC analysis were utilized. Diffusion transport characteristics were evaluated to assess the swelling ability of the matrices and the release of diclofenac sodium. To examine the release parameters, mathematical modeling was performed by using the Korsmayer–Peppas and Logistic equations as well. During the turbidity study, stoichiometry compositions were selected for the developed IPECs EPO/PecA and EPO/PecC at pH values = 4.0, 5.0, 6.0, and 7.0. The FTIR spectra of the complexes were characterized by an increase in the intensity of the bands at 1610 cm−1 and 1400 cm−1. According to the DSC analysis, IPEC has a certain Tg = 57.3 °C. The highest release rates were obtained for IPEC EPO/PecC_1 and EPO/PecC_4. The mechanism of drug transport from the matrices IPEC EPO/PecC, IPEC EPO/PecA_3, and EPO/PecA_4 can be characterized as Super Case II. Anomalous release (non-Fickian release) is typical for IPEC EPO/PecA_1 and EPO/PecA_2. Thus, the resulting systems can be further used for the effective delivery of the drugs to the colon.

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Biodegradable Hydrogels Based on Chitosan and Pectin for Cisplatin Delivery

Cited by 6 publications

References 33 publications

Exploring the Potential of Artificial Intelligence for Hydrogel Development—A Short Review

Exploring the Potential of Artificial Intelligence for Hydrogel Development—A Short Review

Chitosan-Based Hydrogel in the Management of Dermal Infections: A Review

Characteristics of Interpolyelectrolyte Complexes Based on Different Types of Pectin with Eudragit® EPO as Novel Carriers for Colon-Specific Drug Delivery

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