Synthesis and properties of bi- and tricyclic 1,3-thiazoline/thiazolidine assemblies linked by an exocyclic С=С double bond

Tandem Michael addition/elimination – novel reactivity of pyridinium ylides in reaction with electron-deficient alkenes

“…Functionalized thiazolidin-4-ones, including their heteroannulated analogues, are attractive targets for synthetic and medicinal chemistry due to their various biological activities. 8 Previous studies of antitumor activity of imidazothiazolotriazines (namely, derivatives of imidazo[4,5- e ]thiazolo[3,2- b ]-1,2,4-triazines and imidazo[4,5- e ]thiazolo[2,3- c ]-1,2,4-triazines) revealed their high cytotoxicity against 60 human cancer cells (including Leukemia, Non-Small Cell Lung Cancer, Colon Cancer, CNS Cancer, Melanoma, Ovarian Cancer, Renal Cancer, Prostate Cancer and Breast Cancer). 9…”