Synthesis and Preliminary Evaluation of Benzimidazole Derivatives as Antimicrobial Agents.

Abstract

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Antimicrobial Activity of a New Combination System of Benzimidazole and Various Azoles

“…Recent studies have confirmed that its derivatives are effective against various strains of microorganisms [7][8][9][10][11][12][13][14][15][16]. The basis of a special interest of researchers toward benzimidazole derivatives has been 5,6-dimethylbenzimidazole, which is a fragment of cyanocobalamine (vitamin B 12 ) that is capable of inducing the growth of bacteria.…”

Synthesis, physicochemical properties and antimicrobial activity of some new benzimidazole derivatives

“…Extensive biochemical and pharmacological studies have confirmed that benzimidazole molecules are effective against various strains of microorganisms [1][2][3][4][5][6][7][8]. Benzimidazoles are regarded as a promising class of bioactive heterocyclic compounds that exhibit a range of biological activities.…”

Effect of Substitution on the Antimycobacterial Activity of 2-(Substituted benzyl)sulfanyl Benzimidazoles, Benzoxazoles, and Benzothiazoles-A Quantitative Structure-Activity Relationship Study

“…benzyl)sulfanyl benzimidazole (BIM), 5) 5-methylbenzimidazole (5-Me-BIM), 6) benzoxazole (BOZ), 7) and some benzothiazole (BTZ) 8) …”

“…This increase of MDR-TB and emergence of XDR-TB provide the rationale to search for new antimycobacterial drugs. [2][3][4] Previously, we have reported the synthesis of 2-(substituted benzyl)sulfanyl derivatives of benzimidazole, 5) 5-methylbenzimidazole, 6) benzoxazole, 7) and benzothiazole 8) (XϭH, 4-NO 2 , 3-NO 2 , 2-NO 2 , 3,5-(NO 2 ) 2 , 2,4-(NO 2 ) 2 , 4-CN, 3-CN, only). General structure of these compounds is shown in Fig.…”