Synthesis and Prediction of the Biological Activity of Heterocyclic N-Derivatives Naphthoquinone

Polish, Nataliia; Марінцова, Н. Г.; Журахівська, Л. Р.; Novikov, Volodymyr; Вовк, М. В.

doi:10.23939/ctas2019.01.069

CTAS

2019

DOI: 10.23939/ctas2019.01.069

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Synthesis and Prediction of the Biological Activity of Heterocyclic N-Derivatives Naphthoquinone

Nataliia Polish¹,

Н. Г. Марінцова²,

Л. Р. Журахівська³

et al.

Abstract: Національний університет "Львівська політехніка", кафедра технології біологічно активних сполук, фармації та біотехнології 2 Інститут органічної хімії НАН України,

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Antioxidant activity of heterocyclic amino containing derivatives of naphthoquinone and their compositions with surface-active rhamnolipids

Polish¹,

Марінцова²,

Karkhut³

et al. 2021

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Composite preparations based on heterocyclic amine-containing naphthoquinone derivatives and surfactant rhamnolipids were obtained. The intensity of the processes of lipid peroxidation (LPO), oxidative modification of proteins (OMB) and radical-absorbing activity against 1,1-diphenyl-2-picrylhydrazyl (DFPG) was studied. Compounds exhibiting high antioxidant activity against LPO and OMB processes were identified, namely: 2-[(6-(4-fluorophenyl-5-oxo-2,5-dihydro-1,2,4-triazin-3-yl) phenyl)amino]naphthalene-1,4-dione 1d and its composite preparation with rhamnolipid 1d + RL. It was found that all synthesized compounds show antioxidant activity in LPO processes.

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Antioxidant activity of heterocyclic amino containing derivatives of naphthoquinone and their compositions with surface-active rhamnolipids

Polish¹,

Марінцова²,

Karkhut³

et al. 2021

CTAS

Self Cite

View full text Add to dashboard Cite

show abstract

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Synthesis and Prediction of the Biological Activity of Heterocyclic N-Derivatives Naphthoquinone

Cited by 1 publication

References 14 publications

Antioxidant activity of heterocyclic amino containing derivatives of naphthoquinone and their compositions with surface-active rhamnolipids

Antioxidant activity of heterocyclic amino containing derivatives of naphthoquinone and their compositions with surface-active rhamnolipids

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