Synthesis and potent antimicrobial activity of CoFe2O4 nanoparticles under visible light

Abstract

The nanoparticles of Cobalt ferrite are synthesized using polyethylene glycol as a solvent by the solvothermal method in a surfactant-free condition. Nanoparticles that were synthesized were determined by using various techniques such as Diffuse Reflection Spectroscopy (DRS), X-Ray Diffraction (XRD), Scanning Electron Microscope (SEM), and Energy Dispersive X-ray spectroscopy (EDAX). The Scanning electron microscope confirmed the range of spherical nanoparticles in the size of 20–33 nm. An excellent match was observed between the calculated particles size in the X-ray diffraction and electron microscopes results. Furthermore, their antimicrobial efficacy was determined by MIC, MBC, IC50 and disc diffusion method on Gram-negative ( Pseudomonas aeruginosa and Escherichia coli ) and Gram-positive ( Staphylococcus aureus, Bacillus cereus ) bacteria. The results indicated an acceptable bacteriostatic and bactericidal effects of this nanoparticles. Additionally, it was seen that by the increase in the concentration of nanoparticles, their antimicrobial property would increase. Background and objective In recent years, antibacterial materials have found a special place to avoid the overuse of antibiotics. In this study, the antibacterial effects of CoFe 2 O 4 nanoparticles on Staphylococcus aureus, Escherichia coli, Pseudomonas aeruginosa, and Bacillus cereus, were investigated due to their importance as human pathogens in nosocomial infection. Methodology In this study, the antibacterial effects of CoFe 2 O 4 nanoparticles such as MIC, MBC, IC50, and disc diffusion method were examined. Findings According to the results, CoFe 2 O 4 nanoparticles exhibited potent antibacterial activity against the bacteria that were examined, especially Bacillus cereus . The MBC (Minimum Bactericidal Concentration) of CoFe 2 O 4 nanoparticle on Escherichia coli , Staphylococcus aureus , Pseudomonas aeruginosa , Bacillus cereus was between 0.12-0.48 mg/ml and MIC (Minimum Inhibition Concentration) on these bacteria detected between 0.06-0.24 mg/ml. The least IC50 determined for Bacillus cereus with a concentration of 0.061 mg/ml. Pseudomonas aeruginosa and Bacillus cereus identified as the most resistant and sensitive bacteria in the disc diffusion method, respectively.

Synthesis of CoFe2O4/BiOI nanocomposite; Its application as an antibacterial agent

“…The final precipitate was thoroughly dried in a free medium for 1 day before being heated at 450°C for 2 h to yield CoFe 2 O 4 magnetic nanoparticles. [ 18 ] Polyethylene glycol (PEG) and sulfonic acid was used as solvent. It is noteworthy that the synthesis was performed by the heat dissolution method without surfactant.…”

Recent advances in synthesis of quinazoline‐2,4(1H,3H)‐diones: Versatile building blocks in N‐heterocyclic compounds

“…[ 20 ] Quinazoline‐2,4( 1H,3H )‐diones also exhibit a wide variety of biological functions like α 1 ‐antagonist, [ 21 ] bacterial gyrase/topoisomerase inhibitors, [ 22,23 ] AMPA and kainate (KA) receptor antagonists, [ 24 ] PGGTase‐I inhibitors, [ 25 ] NAPE‐PLD inhibitors, [ 26 ] inhibitors of non‐small‐cell lung cancer, [ 27 ] and inhibitors of the growth of multiple human tumor cell lines, [ 28 ] and some of them have acted as nucleoside analogues, [ 29 ] fluorescent bioprobes for visualization of puromycin‐sensitive aminopeptidase in living cells, [ 30 ] and fluorescent base analogue (FBA) probes of nucleic acids' structures. [ 31 ] They also have attracted interest in preparing various pharmacological activities, such as antiviral, [ 32 ] antibacterial, [ 33–35 ] anticonvulsant and antioxidant agents, [ 36 ] and antitumor. [ 37 ]…”

Structural, morphological and magnetic investigations on cobalt ferrite nanoparticles obtained through green synthesis routes

“…Cobalt ferrite nanoparticles are used in electronic devices (energy storage, microwave devices, sensors and biosensors, recording media), for the removal of toxic pollutants from water, in biomedical applications for drug delivery and hyperthermia [1][2][3]. Recent studies revealed the antibacterial properties of the cobalt ferrite nanoparticles on multidrug resistant bacterial strains [4]. For biomedical applications, it is required to modify the surface of the cobalt ferrite nanoparticles by various bioactive and biocompatible molecules [5].…”