Synthesis and Physicochemical Properties of Novel S-Substituted Bis-1,2,4-Triazoles

Abstract

The aim of the work was to describe the method of combining two 1,2,4-triazole systems in a molecule, the alkylation reaction of the thiol group to obtain the previously undiscovered S-derivatives of 1,2,4-triazole and the fragmentation pathway of the substances under hard ionization using gas chromatography-mass spectrometry. The structures of the synthesized compounds were confirmed by elemental analysis, 1H and 13C NMR spectroscopy and GC-MS analysis. The characteristic signals for S-alkyl residues were observed in the region typical for aliphatic compounds. The fragmentation of molecules was represented by the gradual cleavage of radicals and the opening of the second 1,2,4-triazole heterocycle.

Evaluation Of Antioxidant Activity Of 1, 2, 4-Triazole Derivatives With Morpholine Moiety

“…This nitrogen-containing, heterocyclic system is increasingly attracting the attention of scientists, which based at their level of a wide and pronounced range of biological and pharmacological [8][9][10][11][12][13][14] actions and low toxicity parameters [7,11,15]. 1,2,4-Triazole derivatives are quite convenient agents in terms of "fine" organic synthesis [16][17][18] and in terms of relative safety of reagents [19,20]. Therefore, based on the results of synthetic scientific schools [4,[6][7][8][9][10][11] and our own work [12][13][14][15]18], we considered it appropriate to study the antioxidant activity (AOA) of 4-R-3-(morpholinomethyl)-4H-1,2,4-triazole-5-thioles and their alkyl derivatives in vitro using the method of non-enzymatic initiation of lipid peroxidation.…”