The aim of the work was to study the antioxidant activity of 4-R-3-(morpholinomethyl)-4H-1,2,4-triazole-5-thioles and their alkyl derivatives in vitro using the method of non-enzymatic initiation of lipid peroxidation. Among the 45 compounds studied, 8 showed varying degrees of AOA. The most pronounced AOA has 4-amino-3-(morpholinomethyl)-4H-1,2,4-triazole-5-thiol. It was found that in most cases the introduction in alkyl-derivatives of 4-R-3-(morpholinomethyl)-4H-1,2,4-triazole-5-thioles free amino group or phenyl substituent to the N4 atom of the 1,2,4-triazole nucleus, accompanied with increasing of AOA for test substances. In almost all cases, the presence on the N4 atom of 1,2,4-triazole nucleus methyl or ethyl groups has the opposite effect, even in comparison with control groups.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.