Synthesis and physicochemical evaluation of octenylsuccinated kappa-carrageenan: Conventional versus microwave heating

Toumi, Selma; Yahoum, Madiha Melha; Lefnaoui, Sonia; Hadjsadok, Abdelkader

doi:10.1016/j.carbpol.2022.119310

Cited by 10 publications

(12 citation statements)

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“…This contributes to the unfolding of the chains by expelling anionic polar groups in an aqueous medium, and therefore, the electrostatic repulsion becomes preponderant, which will result in a decreased viscosity by the disentanglement of the polymeric network. These results are not totally in agreement with previous works related to the hydrophobic modification of xanthan by Sara et al [ 26 ] and Toumi et al [ 27 , 29 ] for kappa-carrageenan. This may be because, in these works, the length of the hydrophobic octyl moieties is more important than that of benzyl groups, which resulted in stronger associative forces that increased with increased DS.…”

Section: Resultscontrasting

confidence: 81%

Experimental Analysis and Neural Network Modeling of the Rheological Behavior of Xanthan Gum and Its Derivatives

et al. 2023

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The main objective of this study was to create a mathematical tool that could be used with experimental data to predict the rheological flow behavior of functionalized xanthan gum according to the types of chemical groups grafted onto its backbone. Different rheological and physicochemical analyses were applied to assess six derivatives synthesized via the etherification of xanthan gum by hydrophobic benzylation with benzyl chloride and carboxymethylation with monochloroacetic acid at three (regent/polymer) ratios R equal to 2.4 and 6. Results from the FTIR study verified that xanthan gum had been modified. The degree of substitution (DS) values varying between 0.2 and 2.9 for carboxymethylxanthan gum derivatives were found to be higher than that of hydrophobically modified benzyl xanthan gum for which the DS ranged from 0.5 to 1. The molecular weights of all the derivatives were found to be less than that of xanthan gum for the two types of derivatives, decreasing further as the degree of substitution (DS) increased. However, the benzyl xanthan gum derivatives presented higher molecular weights varying between 1,373,146 (g/mol) and 1,262,227 (g/mol) than carboxymethylxanthan gum derivatives (1,326,722–1,015,544) (g/mol). A shear-thinning behavior was observed in the derivatives, and the derivatives’ viscosity was found to decrease with increasing DS. The second objective of this research was to create an ANN model to predict one of the rheological properties (the apparent viscosity). The significance of the ANN model (R2 = 0.99998 and MSE = 5.95 × 10−3) was validated by comparing experimental results with the predicted ones. The results showed that the model was an efficient tool for predicting rheological flow behavior.

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Section: Resultscontrasting

confidence: 81%

Experimental Analysis and Neural Network Modeling of the Rheological Behavior of Xanthan Gum and Its Derivatives

et al. 2023

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“…The FTIR spectrum of xanthan gum (XG) shows characteristic absorption bands at 1015.55 cm −1 , 1407.66 cm −1 , 1602.34 cm −1 and 1732.13 cm −1 , corresponding, respectively, to the elongation of the ether function C–O–C, the C–H bonds of methyl groups and the asymmetric vibrations of COO–, as well as the elongation of CO esters (acetyls). The characteristic peak at 3317.00 cm −1 is attributed to the elongation of the OH hydroxyl groups [ 34 , 35 , 36 , 37 ].…”

Section: Resultsmentioning

confidence: 99%

“…The appearance of the main characteristic peaks of MTH and XG on the spectrum of the mixture (MTH/XG) was noticed ( Figure 1 ), with the observation of the N–H stretching of the primary amine group of metformin in the range of 3400 to 3100 cm −1 , along with the presence of two bands at 1038 cm −1 and 1166 cm −1 [ 38 ] ascribed to C–N stretching, as well as the N–H deformation at 1602.34 cm −1 [ 12 , 16 ]. Characteristic absorption bands of XG were also observed at 1015.55 cm −1 , 1407.66 cm −1 and 1732.13 cm −1 , corresponding, respectively, to the elongation of the ether COC function, the CH bonds of the methyl groups [ 39 ] and the asymmetric vibrations of COO–, as well as the elongation of the acetyl group [ 34 , 35 , 36 , 37 ]. The FTIR spectra of the formulated microspheres, depicted in Figure 2 , also demonstrate the absence of interactions between XG and MTH.…”

Section: Resultsmentioning

confidence: 99%

Formulation and Evaluation of Xanthan Gum Microspheres for the Sustained Release of Metformin Hydrochloride

et al. 2023

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This work aimed to formulate xanthan gum microspheres for the encapsulation of metformin hydrochloride, according to the process of ionotropic gelation. The obtained microparticles, based on various fractions of xanthan gum (0.5–1.25), were subjected to different physico-chemical tests and a drug release study. Microspheres with an average size varying between 110.96 μm and 208.27 μm were obtained. Encapsulation efficiency reached 93.11% at a 1.25% biopolymer concentration. The swelling study showed a swelling rate reaching 29.8% in the gastric medium (pH 1.2) and 360% in the intestinal medium (pH 6.8). The drug release studies showed complete metformin hydrochloride release from the beads, especially those prepared from xanthan gum at the concentration of 1.25%, in intestinal medium at 90.00% after 6 h. However, limited and insignificant drug release was observed within the gastric medium (32.50%). The dissolution profiles showed sustained release kinetics.

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“…As shown in Figure 1 a, two new absorption bands have appeared in the spectrum of OSSPG in comparison to the spectrum of SPG. A sharp peak at 1718 cm −1 in the spectrum of OSSPG is attributed to the C=O stretching vibration of the carboxylic group of OSA [ 25 ]. The absorption band around 1580 cm −1 for OSSPG can be ascribed to the asymmetric stretch vibration of carboxylate (RCOO−) [ 36 ], which proves the successful esterification of SPG.…”

Section: Resultsmentioning

confidence: 99%

“…Octenyl succinic anhydride (OSA), recognized as a green esterification agent, is a compound with high chemical activity due to its carbon–carbon double bond and carboxylic-acid-matching bond, with the advantages of being a less-toxic organic solvent, and can be easily applied in subsequent treatments [ 23 , 24 ]. The study of octenenyl succinic anhydride modified polysaccharide includes carrageenan [ 25 ], Arabic gum [ 26 ], and starch [ 27 ], which have all been well studied. In particular, octenenyl succinic anhydride-modified starch has been successfully applied in the food industry.…”

Section: Introductionmentioning

confidence: 99%

Production and Anti-Inflammatory Performance of PVA Hydrogels Loaded with Curcumin Encapsulated in Octenyl Succinic Anhydride Modified Schizophyllan as Wound Dressings

Yifeng

Deng

et al. 2023

Molecules

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Amphiphilic polysaccharides can be used as wall materials and applied to encapsulate hydrophobic active chemicals; moreover, there is significant demand for novel medical high-molecular-weight materials with various functions. In order to prepare amphiphilic schizophyllan (SPG), octenyl succinic anhydride (OSA) was chosen to synthesize OSA-modified schizophyllan (OSSPG) using an esterified reaction. The modification of OSSPG was demonstrated through FT-IR and thermal analysis. Moreover, it was found that OSSPG has a better capacity for loading curcumin, and the loading amount was 20 μg/mg, which was 2.6 times higher than that of SPG. In addition, a hydrogel made up of PVA, borax, and C-OSSPG (OSSPG loaded with curcumin) was prepared by means of the one-pot method, based on the biological effects of curcumin and the immune-activating properties of SPG. The mechanical properties and biological activity of the hydrogel were investigated. The experimental results show that the dynamic cross-linking of PVA and borax provided the C-OSSPG/BP hydrogel dressing with exceptional self-healing properties, and it was discovered that the C-OSSPG content increased the hydrogel’s swelling and moisturizing properties. In fibroblast cell tests, the cells treated with hydrogel had survival rates of 80% or above. Furthermore, a hydrogel containing C-OSSPG could effectively promote cell migration. Due to the excellent anti-inflammatory properties of curcumin, the hydrogel also significantly reduces the generation of inflammatory factors, such as TNF-α and IL-6, and thus has a potential application as a wound dressing medicinal material.

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Synthesis and physicochemical evaluation of octenylsuccinated kappa-carrageenan: Conventional versus microwave heating

Cited by 10 publications

References 82 publications

Experimental Analysis and Neural Network Modeling of the Rheological Behavior of Xanthan Gum and Its Derivatives

Experimental Analysis and Neural Network Modeling of the Rheological Behavior of Xanthan Gum and Its Derivatives

Formulation and Evaluation of Xanthan Gum Microspheres for the Sustained Release of Metformin Hydrochloride

Production and Anti-Inflammatory Performance of PVA Hydrogels Loaded with Curcumin Encapsulated in Octenyl Succinic Anhydride Modified Schizophyllan as Wound Dressings

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