Synthesis and Physico‐chemical Studies on a 15‐Membered Hexaaza Macrocyclic Ligand Derived from Hydrazine and Its Complexes with Co(II), Ni(II), Cu(II), and Zn(II)

Shakir, Mohammad; Begum, Nishat; Parveen, Shama; Chingsubam, Poonam; Tabassum, Shabana

doi:10.1081/sim-120039262

Cited by 17 publications

(5 citation statements)

References 26 publications

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“…This was apparent from the related bands at 765–779 and 1578–1608 cm −1 48 . The ν(M–N) binding was confirmed by the formation of a related peak at 470–530 cm −1 49 . Another two peaks at 1500–1525 and 3030–3050 cm −1 were respectively formed to describe ν(C=C) and ν(C–H) of the pyridyl ring.…”

Section: Resultsmentioning

confidence: 71%

“…48 The ν(M-N) binding was confirmed by the formation of a related peak at 470-530 cm À1 . 49 Another two peaks at 1500-1525 and 3030-3050 cm À1 were respectively formed to describe ν(C=C) and ν(C-H) of the pyridyl ring. Moreover, two bands were observed at 1385-1420 and 1615-1660 cm À1 revealing the symmetric and antisymmetric stretching modes of free amino acid ν(C=O) band, respectively.…”

Section: Characterization Of [Cu (Bpy) (Phenala)cl]2h 2 O Complexmentioning

confidence: 99%

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Spectroscopic and electrochemical investigation of ternary Cu (II) complex interaction with calf thymus DNA

Mostafa

Abdelaziz

Qutb

et al. 2023

Applied Organom Chemis

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Aiming to design unique metallic drugs with significant therapeutic activity, in this work, mixed ligand Cu (II) complex involving 2,2′‐bipyridine and phenylalanine [Cu (bpy) (phenala.)Cl].2H2O has been fabricated and characterized using IR spectroscopy. The interaction of Cu (II) complex with CT‐DNA molecules was examined through UV–vis absorption titration plots, thermal denaturation experiments, viscosity measurements, and electrochemical studies. Cyclic voltammetry, electrochemical impedance spectroscopy, and chronoamperometry measurements have been exploited to elucidate their binding style. The negative potential shift in ΔE and E1/2 values as well as the increased current density of Cu (II)/Cu(I) redox couple suggested the promoted rate of electron transfer process in presence of CT‐DNA molecules in the examined solution. Some kinetic parameters were also estimated such as the diffusion coefficient, the exchange current density, and Tafel slope values. Based on the results of these binding experiments, a groove and/or electrostatic interaction mode was expected. The antimicrobial activity of the studied Cu (II) complex was screened against a series of bacteria and fungi. An outstanding performance was shown when treating different Gram‐positive and Gram‐negative bacteria types. Moreover, an enhanced cytotoxicity behavior toward some human tumor cell lines, including MCF7, HEPG2, and HFB4, was detected with respective IC50 values of 43.02, 51.21, and >200 μM when incubated with Cu (II) complex for 72 h. These results suggest the application of [Cu (bpy) (phenala.)Cl].2H2O complex as a chemotherapeutic agent with a promising output in the drug discovery field.

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Section: Resultsmentioning

confidence: 71%

Section: Characterization Of [Cu (Bpy) (Phenala)cl]2h 2 O Complexmentioning

confidence: 99%

Spectroscopic and electrochemical investigation of ternary Cu (II) complex interaction with calf thymus DNA

Mostafa

Abdelaziz

Qutb

et al. 2023

Applied Organom Chemis

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“…22 This was further supported by the appearance of a new medium intensity band at 475 cm −1 attributable to a Cu-N vibration. 23 Aromatic C=C and C-H stretching vibrations were observed at 1586 and 1438 and 3031 cm −1 , respectively. Methylene C-H stretching frequency of complex was observed at 2920 cm −1 , supported by the presence of bands at 692 and 1398 cm −1 corresponding to its rocking and bending deformations, respectively.…”

Section: Ft-ir Datamentioning

confidence: 95%

Effect of Fluorinated Ligand on Structural, Electronic and DNA-binding Properties of Copper Paddlewheel Complex: Synthesis, Structure and Properties

Iqbal

Ali

Tahir

2018

ACSi

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This paper presents synthesis, structural description and properties of a binuclear paddlewheel copper(II) carboxylate complex with formula [(py)Cu(μ-L) 4 Cu(py)], where py = pyridine and L = 4-fluorophenylacetate. Structural characteristics, electronic absorption and DNA-binding properties of the synthesized complex have been compared to those of the non-fluorinated analogues (where F is replaced by H,-CH 3 and-OCH 3) already reported and the modifications successfully ascribed to fluorine. The complex exhibits typical paddlewheel structure and there are two crystallographically independent molecules in the unit cell. The electronic absorption spectrum of complex is also different and the mode and extent of DNA-binding ability of complex are significantly altered owing to the presence of suitably substituted fluorine. The effect of fluorine is clearly manifested in the modified properties of synthesized complex.

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“…Which occurs at(1185,1252) cm -1 ,(1234,1247) cm -1 and (1165,1235) cm -1 for(H2L 1 , H2L 2 and H2L 3 ) respectively. Thus, it can be concluded that the Schiff bases are tetradentate coordinating via the azomethine N and the phenolic O [28].Assignment of the proposed coordination sites is further supported by the appearance of new band at (432-472) cm -1 and(501-570) cm -1 which could be attributed to υ (M-N) and υ(M-O) respectively [29,30]…”

Section: Ir Spectramentioning

confidence: 96%

Preparation and Characterization of Co(II), Ni(II),Cu(II) and Zn(II) Complexes with Unsymmetrical Tetradentate Schiff Bases Ligands

Al-Nama¹,

Nidaa²

2019

J.Edu.Sci.

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Synthesis and Physico‐chemical Studies on a 15‐Membered Hexaaza Macrocyclic Ligand Derived from Hydrazine and Its Complexes with Co(II), Ni(II), Cu(II), and Zn(II)

Cited by 17 publications

References 26 publications

Spectroscopic and electrochemical investigation of ternary Cu (II) complex interaction with calf thymus DNA

Spectroscopic and electrochemical investigation of ternary Cu (II) complex interaction with calf thymus DNA

Effect of Fluorinated Ligand on Structural, Electronic and DNA-binding Properties of Copper Paddlewheel Complex: Synthesis, Structure and Properties

Preparation and Characterization of Co(II), Ni(II),Cu(II) and Zn(II) Complexes with Unsymmetrical Tetradentate Schiff Bases Ligands

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