Synthesis and Physical Properties of Substituted 4-Dimethylaminomethyl-1-phenyl-1-nonen-3-ones Possessing Antitumor Properties

A series of 4-(alkylidene/arylidene)amino-5-(2-furanyl)-2,4-dihydro- 3H-1,2,4-triazole-3-thiones (2) and 6-aryl-3-(2-furanyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines (3) were synthesized. The configuration of 2g was assigned on the basis of 1H-NMR data. Of the new derivatives tested, only 2b, 2g, and 4f were found to be active against Staphylococcus aureus and/or Staphylococcus epidermidis (MIC 125-1.95 micrograms/ml), whereas all exhibited varying degrees of antifungal activity (MIC 25-0.8 micrograms/ml).

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Synthesis and Antimicrobial Properties of New 4‐(Alkylidene/arylidene)‐amino‐5‐(2‐furanyl)‐2,4‐dihydro‐3H‐1,2,4‐triazole‐3‐thiones and 6‐Aryl‐3‐(2‐furanyl)‐7H‐1,2,4‐triazolo[3,4‐b][1,3,4]thiadiazines

Ergenç

Ulusoy

Çapan

et al. 1996

Archiv der Pharmazie

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ChemInform Abstract: SYNTHESIS AND PHYSICAL PROPERTIES OF SUBSTITUTED 4‐DIMETHYLAMINOMETHYL‐1‐PHENYL‐1‐NONEN‐3‐ONES, POSSESSING ANTITUMOR PROPERTIES

Dimmock¹,

Taylor²

1974

Chemischer Informationsdienst

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Evaluation of Nuclear‐substituted Styryl Ketones and Related Compounds for Antitumor and Cytotoxic Properties

Dimmock¹,

Taylor²

1975

Journal of Pharmaceutical Sciences

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Synthesis and Physical Properties of Substituted 4-Dimethylaminomethyl-1-phenyl-1-nonen-3-ones Possessing Antitumor Properties

Cited by 14 publications

References 26 publications

Synthesis and Antimicrobial Properties of New 4‐(Alkylidene/arylidene)‐amino‐5‐(2‐furanyl)‐2,4‐dihydro‐3H‐1,2,4‐triazole‐3‐thiones and 6‐Aryl‐3‐(2‐furanyl)‐7H‐1,2,4‐triazolo[3,4‐b][1,3,4]thiadiazines

Synthesis and Antimicrobial Properties of New 4‐(Alkylidene/arylidene)‐amino‐5‐(2‐furanyl)‐2,4‐dihydro‐3H‐1,2,4‐triazole‐3‐thiones and 6‐Aryl‐3‐(2‐furanyl)‐7H‐1,2,4‐triazolo[3,4‐b][1,3,4]thiadiazines

ChemInform Abstract: SYNTHESIS AND PHYSICAL PROPERTIES OF SUBSTITUTED 4‐DIMETHYLAMINOMETHYL‐1‐PHENYL‐1‐NONEN‐3‐ONES, POSSESSING ANTITUMOR PROPERTIES

Evaluation of Nuclear‐substituted Styryl Ketones and Related Compounds for Antitumor and Cytotoxic Properties

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