Synthesis and Antimicrobial Properties of New 4‐(Alkylidene/arylidene)‐amino‐5‐(2‐furanyl)‐2,4‐dihydro‐3H‐1,2,4‐triazole‐3‐thiones and 6‐Aryl‐3‐(2‐furanyl)‐7H‐1,2,4‐triazolo[3,4‐b][1,3,4]thiadiazines

Abstract

A series of 4-(alkylidene/arylidene)amino-5-(2-furanyl)-2,4-dihydro- 3H-1,2,4-triazole-3-thiones (2) and 6-aryl-3-(2-furanyl)-7H-1,2,4-triazolo[3,4-b][1,3,4]thiadiazines (3) were synthesized. The configuration of 2g was assigned on the basis of 1H-NMR data. Of the new derivatives tested, only 2b, 2g, and 4f were found to be active against Staphylococcus aureus and/or Staphylococcus epidermidis (MIC 125-1.95 micrograms/ml), whereas all exhibited varying degrees of antifungal activity (MIC 25-0.8 micrograms/ml).

Synthesis and crystal structure of novel schiff bases derived from 3‐(2‐ethoxyphenyl)‐4‐amino‐5‐mercapto‐4H‐1,2,4‐triazole

“…Schiff bases and their complexes are becoming increasingly important as biochemical, analytical and antimicrobial reagents [9], and have been amongst the most widely studied coordination compounds in recent years. Further, many Schiff bases of 1,2,4-triazoles were found to possess potent activities such as herbicidal, pesticidal, plantgrowth regulating [10,11]. In particular, Schiff bases derived from triazoles are more and more interesting because of their broad spectra of biological activities.…”

Crystal structure of (E)-N-(4-(dimethylamino)benzylidene)-3-(2,4-dinitrophenylthio)-5-(4-methoxyphenyl)-4H-1,2,4-triazol-4-amine, C24H21N7O5S

“…Af ew (E)-N-benzylidene-3-alkylthio-5-substituted-4H-1,2,4-triazol-4-amines have been reported to exhibit antifungal activity [2,3], antimicrobial properties [4,5], anticonvulsant activity [6], and antitumour effects [7]. It is to be expected that their arylsubstituted analogues (E)-N-benzylidene-3-arylthio-5-substituted-4H-1,2,4-triazol-4-amines can exhibit the superposition of diversiform biological and pharmacological activities because they join aryl (containing heterocyclic radical), imine, thioether and other groups.…”

Synthesis, characterization, and antimicrobial evaluation of some new hydrazinecarbothioamide, 1,2,4-triazole and 1,3,4-thiadiazole derivatives

“…In view of these facts and as a continuation of our research on the biological properties of 1,2,4-triazoleand 1,3,4-thiadiazole containing derivatives [12][13][14][15][16][17][18] , we have designed and synthesized a number of imidazo [2,1-b] thiazole substituted fused 1,2,4-triazole and 1,3,4-thiadiazole systems, as potential antibacterial and antifungal agents.…”