Synthesis and pharmacology of modified amidine isoxazoline glycoprotein IIb/IIIa receptor antagonists

One-pot synthesis of new series 3,4,5-trisubstituted–dihydroisoxazoline derivatives via 1,3-dipolar cycloaddition of nitrile oxides with chalcones

“…Among them five-membered heterocycles, isoxazolines are of considerable interest due to their versatile application in pharmaceutical and agrochemical agents. Isoxazoline derivatives have been reported to possess antidiabetic, 1 antiinfluenza virus, 2 antifungal, 3 glycoprotein IIb/IIIa receptor antagonists, 4 antiHIV, 5 spermicidal and antiHIV, 6 analgesic and antiinflammatory, 7 and β-adrenergic receptor antagonist, 8 antitumour, 9 antistress 10 and anticancer properties. 11 Isoxazolines also act as an important building block for the synthesis of biologically active molecules.…”

Synthesis and Antimicrobial Activity of Novel Heterocyclic Sulfamoyl‐phenyl‐carboximidamides Derived from Clinically Applied Sulfonamides

“…Amidine derivatives have antidegenerative [18], antitumor [19], and anti-platelet action [20]. Amidine derivatives have antidegenerative [18], antitumor [19], and anti-platelet action [20].…”

Synthesis of novel isoxazolines via 1,3-dipolar cycloaddition and evaluation of anti-stress activity

“…Previous studies showed that several isoxazoline moieties possessed a wide spectrum of activities like PTP1B inhibitory activity (Ahmad et al, 2006), antimicrobial (Gaonkar et al, 2007), anti-influenza virus (Kai et al, 2001), antifungal (Basappa et al, 2003), glycoprotein IIb/ IIIa receptor antagonists (Sielecki et al, 2001), anti-HIV (Ichiba et al, 1993), spermicidal and anti-HIV (Srivastava et al, 1999), analgesic and anti-inflammatory (Habeeb et al, 2001), and b-adrenergic receptor antagonist properties (Conti et al, 1998). However, their role during stressful condition is unknown.…”