All chemicals were obtained from commercial suppliers and used without further purification. Melting points were determined in open capillaries on a Buchi oil melting point apparatus and are uncorrected. Reactions were monitored by using TLC on aluminum sheets precoated with silica gel 60 F 254 (0.2 mm, Merck). For column chromatography, silica gel of 100-200 mesh size was used and Chromatographic spots were visualized by UV light and/or with iodine. 1 H NMR spectra were acquired on Agilent-NMR-vnmrs 400 MHz instrument in DMSO-d 6 or CDCl 3 . 13 C NMR spectra were recorded on a Bruker AMX-400 (100 MHz) with complete proton decoupling. Chemical shifts are reported in ppm from tetramethylsilane (TMS) with the solvent as the internal reference (CDCl 3 : δ 77.0 ppm or DMSO δ 40.0 ppm). Mass spectrometry was performed with a Bruker-Franzen Esquire LC mass spectrometer unless otherwise stated.

Abstract.We have synthesized a series of novel isoxazolines via 1,3-dipolar cycloaddition reaction. Aromatic aldoximes undergo oxidative-dehydrogenation with chloramine-T to give nitrile oxides, which were reacted with chalcones to afford of 3,4,5-trisubstituted 4,5-dihydroisoxazolines in a good yield.

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Solvent-Free Green Synthesis of Azines and Their Conversion to 2,5-Disubstituted-1,3,4-thiadiazoles. -1,3,4-Thiadiazole derivatives (III) are synthesized via azines (II) by a solvent-free, clean and efficient method under eco-friendly benign reaction conditions in excellent yields. The reaction mechanisms are discussed. -(SHRIDEVI*, D. D.; NINGAIAH, S.; KUDUVA, N. U.; YHYA, R. K.; RAI, K. M. L.; Synth. Commun. 45 (2015) 24, 2869-2875, http://dx.

In this paper, two of the new antipyrine heterocyclic derivatives have been synthesized via the formation of Schiff bases. The Schiff bases compounds were generated from the reaction of 4-Ameno-antipyrine (4-AAP) with 3-hydroxybenzaldehyde and 4-nitrobenzaldehyde, which was converted to imidazolidinone compounds by reaction with glycine. The reactions were monitored by Thin Layer Chromatography (TLC). The structure of the prepared compounds was confirmed by physical and available spectroscopic data, i.e., FTIR, 1 HNMR, 13 C-NMR, GC-Mass and HRMs.