Synthesis and pharmacological study of 1-acetyl/propyl-3-aryl-5-(5-chloro-3-methyl-1-phenyl-1H-pyrazol-4-yl)-2-pyrazoline

Untitled

“…Balakrishna Kalluraya et al 39 synthesized a series of acetyl/propyl pyrazolines carrying 5-aryloxypyrazole moiety (2l) and investigated them for their anti-inflammatory and analgesic activity showing that presence of aryloxy group in the 5th position will decreased the anti-inflammatory and analgesic activity when compared with that of 5-chloro derivatives.…”

“…Girisha et al 46 prepared a series of acetyl/propyl pyrazolines (2s) carrying a pyrazole moiety reporting that compounds bearing electron withdrawing nitro group in the arylmoiety showed the highest analgesic activity. P.K.…”

The Synthesis and Anti-Bacterial Activities of N-carboxymethyl Rhodanines

“…In a subsequent study, we continued with our work towards the modification of N-carboxymethyl rhodanines by introducing different groups at the 5-position of these compounds to give four different series of analogues, including 19a-x, 20a-t, 21a-p and 22a-x ( Figure 11) [50][51][52][53] Molecules containing a pyrazole ring are known to possess a wide variety of biological activities [54,55], and there has been a recent increase in studies directed towards the use of pyrazole derivatives as potential antimicrobial agents [56][57][58][59][60]. With this in mind, we designed and synthesized a new series of pyrazole-based N-carboxymethyl rhodanines (23a-p) and evaluated their antimicrobial activity ( Figure 12) [61].…”

Synthesis and Antibacterial Screening of Novel Fluorine Containing Heterocycles

“…Recently pyrazole and thiazole based pyrazolines have emerged as an attractive lead compounds in drug development due to their antimicrobial activity profile [31][32][33][34] .…”