Synthesis and Pharmacological Evaluation ofN-Phenyl-N′-[1-[3-(1-aryl-4-piperazinyl)propan-2-ol]]ureas

Bosc, Jean-Jacques; Jarry, Christian

doi:10.1002/(sici)1521-4184(19989)331:9<291::aid-ardp291>3.0.co;2-r

Cited by 11 publications

(1 citation statement)

References 9 publications

(12 reference statements)

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“…In fact, the use of oxazoline, thiazoline, and imidazoline building blocks in pharmaceutical drug discovery is continually increasing . Oxazolines are known as important heterocyclic compounds that are used as chemotherapeutic agents especially as analgesic and anti‐inflammatory . A large number of methods are reported for the synthesis of 2‐oxazolines.…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Activity of a New Class of Sulfonylmethane Linked Bisheterocycles

Padmavathi

Seenaiah

Padmaja

2014

Journal of Heterocyclic Chem

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Section: Introductionmentioning

confidence: 99%

Synthesis and Antimicrobial Activity of a New Class of Sulfonylmethane Linked Bisheterocycles

Padmavathi

Seenaiah

Padmaja

2014

Journal of Heterocyclic Chem

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ChemInform Abstract: 2‐Amino‐2‐oxazolines. Part 9. Synthesis and Pharmacological Evaluation of N‐Phenyl‐N′‐[1‐[3‐(1‐aryl‐4‐piperazinyl)propan‐2‐ol]]ureas.

Bosc

Jarry

1999

ChemInform

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1999 pharmacology, medicinal chemistry, vaccines, serums pharmacology, medicinal chemistry, vaccines, serums V 1100 01 -244 2-Amino-2-oxazolines. Part 9. Synthesis and Pharmacological Evaluation of N-Phenyl-N'-[1-[3-(1-aryl-4-piperazinyl)propan-2-ol]]ureas. -The title ureas (I) are screened for antiallergic and analgesic activities. The ureas (Ia)-(Ic) demonstrate potent antiallergic activities while (Ib) and (Id) exhibit a significant dose-dependant analgesic action with an activity almost comparable with that of aspirin. -(BOSC, J. J.; JARRY, C.; Arch. Pharm. (Weinheim, Ger.) 331 (1998) 9, 291-293; Lab. Chim. Phys., Univ. Bordeaux, F-33076 Bordeaux, Fr.; EN)

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DFT study and Monte Carlo simulation on proton transfers of 2‐amino‐2‐oxazoline, 2‐amino‐2‐thiazoline, and 2‐amino‐2‐imidazoline in the gas phase and in water

et al. 2005

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Density functional theory (DFT) and Monte Carlo (MC) simulation with free energy perturbation (FEP) techniques have been used to study the tautomeric proton transfer reaction of 2-amino-2-oxazoline, 2-amino-2-thiazoline, and 2-amino-2-imidazoline in the gas phase and in water. Two reaction pathways were considered: the direct and water-assisted transfers. The optimized structures and thermodynamic properties of stationary points for the title reaction system in the gas phase were calculated at the B3LYP/6-311+G(d, p) level of theory. The potential energy profiles along the minimum energy path in the gas phase and in water were obtained. The study of the solvent effect of water on the proton transfer of 2-amino-2-oxozoline, 2-amino-2-thiazoline, and 2-amino-2-imidazoline indicates that water as a solvent is favorable for the water-assisted process and slows down the rate of the direct transfer pathway.

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Synthesis and Pharmacological Evaluation ofN-Phenyl-N′-[1-[3-(1-aryl-4-piperazinyl)propan-2-ol]]ureas

Cited by 11 publications

References 9 publications

Synthesis and Antimicrobial Activity of a New Class of Sulfonylmethane Linked Bisheterocycles

Synthesis and Antimicrobial Activity of a New Class of Sulfonylmethane Linked Bisheterocycles

ChemInform Abstract: 2‐Amino‐2‐oxazolines. Part 9. Synthesis and Pharmacological Evaluation of N‐Phenyl‐N′‐[1‐[3‐(1‐aryl‐4‐piperazinyl)propan‐2‐ol]]ureas.

DFT study and Monte Carlo simulation on proton transfers of 2‐amino‐2‐oxazoline, 2‐amino‐2‐thiazoline, and 2‐amino‐2‐imidazoline in the gas phase and in water

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