Synthesis and pharmacological evaluation of thieno[2,3-b]pyridine derivatives as novel c-Src inhibitors

Synthesis of 4-Benzo[1,3]Dioxol-5-Ylthieno-[2,3-b]Pyridines

“…The aim of this work was to obtain a new potentially active 1,4-dihydropyridine, pyridine and thieno [2,3-b]pyridine derivatives containing benzo [1,3]dioxol-5-yl group for future structure -activity studies. The structures of synthesized compounds were confirmed by spectroscopic methods.…”

“…Some of them possess cytotoxic [1][2][3][4], antiinflammatory [5,6], antiviral [7], antibacterial [8,9] activity. Others are useful as hypolipoproteinemic and antiatherosclerotic agents [10] and inhibitors of mitogen-activated protein kinase enzymes, and are accordingly of benefit as pharmaceutical agents, especially in the treatment of adverse inflammatory, autoimmune, cardiovascular, proliferative and nociceptive conditions [11].…”

“…Others are useful as hypolipoproteinemic and antiatherosclerotic agents [10] and inhibitors of mitogen-activated protein kinase enzymes, and are accordingly of benefit as pharmaceutical agents, especially in the treatment of adverse inflammatory, autoimmune, cardiovascular, proliferative and nociceptive conditions [11]. On the other hand, 6-alkylsulfanylpyridine derivative containing benzo [1,3]dioxol-5-yl group (LUF 5853) is an adenosine (A1) receptor agonist [12].…”

“…In view of all these facts, we undertook synthesis of benzo [1,3]dioxol-5-yl group containing 6-alkylsulfanyl-1,4-dihydropyridine, 6-alkylsulfanylpyridine, 4,7-dihydrothieno [2,3-b]pyridine and thieno [2,3-b]pyridine for future studies of biological activities.…”

Synthesis of some new Thieno[2,3-b]pyridines, Pyrimidino[4',5':4,5]thieno[2,3-b]pyridine and Pyridines Incorporating 5-Bromobenzofuran-2-yl Moiety

“…The thieno [2,3-b]pyridine derivatives occupy special place and have attracted considerable attention because of their broad pharmacological activities, including anticancer [1][2][3][4][5][6][7][8][9], antiviral [10][11][12][13], anti-inflammatory [14][15][16][17], antimicrobial [18,19], antidiabetic [20][21][22][23], antihypertensive [24][25][26] and osteogenic [27,28] activities, in addition to treatment of CNS disorders [29][30][31]. Also, pyridine derivatives of different heterocyclic nucleus have shown potent pharmacological properties like antifungal [32,33], antitubercular [34], antibacterial [35], antimicrobial [36], insecticida [37].…”