Synthesis and Pharmacological Evaluation of Some New 2‐Phenyl benzimidazoles Derivatives and their Schiff′s Bases

Abstract

Some new 2- phenyl benzimidazole derivatives were synthesised by cyclocondensation with appropriate reagents. The compounds synthesised were identified by1H NMR, FAB Mass and FT-IR spectroscopic techniques. All compounds studied in this work were screened for theirin vitroantimicrobial activities against the standard strains:Staphylococcus aureusATCC - 25923, ATCC - 441 andBacillus subtilisATCC- 6633 as gram positive,Escherichia coliATCC - 11775 andPseudomonas aeruginosaATCC 10145 as gram negative bacteria. Some of the compounds inhibited the growth of gram-positive bacteria (B. subtilisandS. aureus) at MIC values between 25 and 200 mg/mL. Some of the compounds exhibit antimicrobial activity against gram negative bacteria (E. coliandP. Aeruginosa) MIC values between 25 and 200 mg/mL.

Metal-based Antimicrobial Agents: Synthesis, Characterization and Biological Studies of Mannich Base Derivatives of Benzimidazole and Their Metal Complexes

“…The compounds with azomethine group in its structure are known as Schiff bases, which are synthesized by the condensation reaction of primary amines and active carbonyl groups. [10] Schiff bases of benzimidazole have been reported with remarkable antibacterial [11], antimicrobial [12] and antiproliferative [13] activities. In addition to their biological importance, benzimidazoles form stable complexes with various transition metals.…”

Synthesis, Characterization and Computational Studies of Two Triazaspiro Tetracycles

“…6 Reactions of substituted aldehydes with 2-(o-aminophenyl)benzimidazole have been reported to yield Schiff 's bases. 7 The syntheses of 2-(2-nitrophenyl)-1-benzoyl-1H-benzimidazole derivatives and their reduction to the corresponding 2-benzimidazoylbenzamides have been reported. The compounds were cleanly and efficiently converted to the corresponding 6-arylbenzimidazo [1,2-c]quinazolines by microwave activation using SiO 2 -MnO 2 as a solid inorganic support.…”

Synthesis, antimicrobial evaluation and QSAR studies of p-amino benzoic acid derivatives

“…PABA is also having anti-virulent properties and therapeutic effect against typhoid and rickettsial diseases (Akberova et al, 2002). Schiff bases show various biological properties including antibacterial, antifungal antitumor, analgesic and anti-inflammatory activity (Chhonker et al, 2009).…”