Synthesis and pharmacological activity of aminoindanone dimers and related compounds

Development and validation of a new qualitative ELISA screening for multiresidue detection of sulfonamides in food and feed

“…sulfathiazole and sulfamethazine in honey) should be considered. As consequence the congeners which should be detected are: sulfadiazine, sulfadimethoxine, sulfamethazine, sulfamonomethoxine, sulfaquinoxaline and sulfathiazole (Pastor-Navarro et al, 2009;Sheridan et al, 2008;Szczę sna, Rybak-Chmielewska, Wa s, & Pohorecka, 2009). Finally, when different ELISAs, in light of their applicability, are compared, also the term "detectable" should be clarified.…”

N-Cyclopentyl-N-(3-oxo-2,3-dihydro-1H-inden-1-yl)acetamide

“…The title compound was synthesized as reported (Sheridan et al, 2008). N-Bromosuccinimide (672 mg, 3.78 mmol) and a catalytic amount of dibenzoylperoxide were added to a solution of indan-1-one (500 mg, 3.78 mmol) in CCl 4 (15 ml) and the reaction was refluxed for 45 min.…”

“…We have demonstrated that indanone derivatives possess smooth muscle relaxant activity and inhibit mediator release (Sheridan et al, 1990(Sheridan et al, , 1999a(Sheridan et al, , 1999bFrankish et al, 2004). In a recent study on bioactivity we evaluated the smooth muscle relaxant activity and mediator release inhibition activities demonstrated by a series of aminoindanones (Simplício et al, 2004;Sheridan et al, 2008).…”

Mast cell stabilisers

“…Our efforts and that of others stemmed from using Nature's reservoir of relatively simple molecules to design synthetic derivatives with enhanced activity over that of their naturally derived precursors. In particular, the promising activity stemming from initial studies on the pterosin family of compounds, in particular, pterosin Z (Sheridan et al, 1999) led to the fruitful discovery of multiple families of benzocycloalkanol dimers arising from a series of manipulations to combinations of indanone (Sheridan et al, 2008(Sheridan et al, , 2009a(Sheridan et al, , 2009b, tetralone and benzosuberone (Barlow &Walsh 2008;Barlow & Walsh 2010;Barlow et al 2011a and 2011b) derived building blocks. These dimer based compounds inevitably required that the initial steps in their preparation revolved around a directed aldol condensation reaction to furnish the dimer, followed by a based catalysed alkylation reaction and carbonyl reduction to afford the alcohol series of dimers (Sheridan et al, 2009a).…”