The durability of polymer electrolyte membrane fuel cell with Pt catalysts supported on carbon nanotube (CNT) was investigated after a few hundred accelerated cell reversal process (RP) cycles generated by hydrogen deficiency. A variety of characterization techniques, including cell performance tests, were applied to examine the effects of CNT support on the degradation of Pt catalysts: transmission electron microscopy, electrochemical impedance spectroscopy, and cyclic voltammetry. During the RP cycle tests, most degradation by carbon corrosion occurred at the outlet region of membrane electrode assembly (MEA) where hydrogen starvation seriously occurred. By using the CNT as the support of Pt catalysts in the MEA cathode, carbon corrosion was reduced and growth of Pt particles by agglomeration and sintering significantly decreased. Compared to a commercial Pt/C catalyst, the cell durability of the Pt/CNT catalyst was enhanced under the RP condition.