Synthesis and oxidant properties of novel (5-bromobenzofuran-2-yl)(3-methyl-3-mesitylcyclobutyl)ketonethiosemicarbazone

Karataş, Fikret; Koca, Murat; Kara, Haki; Servi, Süleyman

doi:10.1016/j.ejmech.2006.01.003

Cited by 49 publications

(20 citation statements)

References 25 publications

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“…We found that MDA levels in serum, liver, and kidney increased compared with control groups at all injection times after rats had been injected with 3-(1H-pyrrol-2-yl)-1H-indazole. Increased MDA might be an indicator of lipid peroxidation, as previously suggested [27][28][29][30]. While vitamins A, E, and C levels decrease, MDA level increase in liver and kidney from the third injection can be a sign of maximum of stress.…”

Section: Discussionmentioning

confidence: 71%

Effect of 3-(1H-Pyrrol-2-yl)-1H-Indazole on the Antioxidant Status of Rats

Karataş

Çöteli

Aydın

et al. 2009

Biol Trace Elem Res

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The influence of injection periods of 3-(1H-pyrrol-2-yl)-1H-indazole regarding vitamins A, E, C, selenium (Se), malondialdehyde (MDA) levels, and glutathione peroxidase (GSH-Px) activity in rats has been investigated. The substance was given by subcutaneous injection at 20 mg/kg every other day for a total of 15 injections. At the end of the treatment, Se levels in serum were determined by fluorimetry, and those of vitamins A, E, C, and malondialdehyde in serum, liver, and kidney were determined by high-performance liquid chromatography. GSH-Px activities in erythrocytes were determined spectrophotometrically. Vitamins A, E, C, and Se levels were generally lower than in the controls, while GSH-Px activity at the third injection period was maximally increased, with the activities after the other injection periods being higher than in the control group. In addition, vitamins A, E, and C levels were generally lower than the control groups, while serum, liver, and kidney MDA levels gradually increased depending on injection periods. On the other hand, GSH-Px activity was higher than in the control group. Thus, the results show that while vitamins A, E, C, and Se levels decreased, MDA levels and GSH-Px activities increased after administration of 3-(1H-pyrrol-2-yl)-1H-indazole to the rats. These findings might be related to the increased amount of free radicals caused by 3-(1H-pyrrol-2-yl)-1H-indazole injection.

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Section: Discussionmentioning

confidence: 71%

Effect of 3-(1H-Pyrrol-2-yl)-1H-Indazole on the Antioxidant Status of Rats

Karataş

Çöteli

Aydın

et al. 2009

Biol Trace Elem Res

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“…Decreased antioxidant vitamin levels might result to the getting rid off metabolic stress because vitamins A, C, and E are major nonenzymatic antioxidants in the body [16]. Several previous studies showed that increasing MDA levels decreases the vitamins A, E, and C levels in serum rat [17,18] because vitamin A and C, like α-tocopherol, stops lipid peroxidation by trapping the free radicals. Vitamin C regenerates α-tocopherol from α-tocopheroxyl radical [30].…”

Section: Discussionmentioning

confidence: 97%

“…In previous studies, we investigated the effect on the levels of vitamins A, E, C, Se, and GSH-Px of some newly synthesized compounds [17,18]. The 2-furan-1H-benzimidazole also synthesized a compound that bears a π-conjugation between furan and phenyl rings.…”

Section: Introductionmentioning

confidence: 98%

Investigation of Oxidative Status of the 2-Furan-2-yl-1H-Benzimidazole in Rats

Karataş

Servi

Kara

et al. 2008

Biol Trace Elem Res

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We investigated the influence of 2-furan-2-yl-1H-benzimidazole regarding vitamins A, E, C, selenium (Se), malondialdehyde (MDA), and glutathione peroxidase (GSH-Px) levels on rats. 2-Furan-2-yl-1H-benzimidazole was given to rats by subcutaneous injection every other day for a total of 22 injections. At the end of the experiment, Se levels were determined by using a fluorimetric method. Serum levels of vitamins A, E, C, and malondialdehyde (MDA) were determined by high-performance liquid chromatography. Glutathione peroxidase (GSH-Px) levels of erythrocytes were spectrophotometrically determined. Our experimental results showed that vitamins A, E, C, and Se levels were found generally lower than the control groups, while serum MDA level and GSH-Px activity flexibly increased, which is dependent on injection days. The observed decreases in vitamins A, E, C, and Se levels in the blood might be causally related to the increased amount of free radicals that are generated with 2-furan-2-yl-1H-benzimidazole injection. However, further investigations are needed to clarify the significance of this observation in respect with the 2-furan-2-yl-1H-benzimidazole injection.

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“…Substituted benzofurans have found some applications such as a fluorescent sensor [1], oxidant [2], brightening agent, a variety of drugs and in other fields of chemistry and agriculture [3]. Benzofurans occur many natural products.…”

Section: Introductionmentioning

confidence: 99%

Green and One-Pot Electrochemical Synthesis of New Benzofurans Based on an ECC Mechanism

Rajabi

Radmannia

Ameri

et al. 2015

Progress in Reaction Kinetics and Mechanism

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The electrochemical oxidation of quinizarine has been studied in the presence of methyl cyanoacetate and ethyl cyanoacetate acting as a nucleophile in acetate buffer solution mixed with ethanol (30/70 v/v) using cyclic voltammetry and controlled-potential coulometry methods. The results revealed that anthracene-1,4,9,10-tetraone derived from the electro-oxidation of quinizarin participates in 1,4-Michael addition reactions with cyanoacetate derivatives. The adducts formed convert to the corresponding benzofuran derivatives through an ECC (Electrochemical, Chemical, Chemical reaction) mechanism. In the present study, benzofuran derivatives were synthesised in good yields using controlled potential electro-oxidation at three graphite electrode in an undivided cell under mild conditions.

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Synthesis and oxidant properties of novel (5-bromobenzofuran-2-yl)(3-methyl-3-mesitylcyclobutyl)ketonethiosemicarbazone

Cited by 49 publications

References 25 publications

Effect of 3-(1H-Pyrrol-2-yl)-1H-Indazole on the Antioxidant Status of Rats

Effect of 3-(1H-Pyrrol-2-yl)-1H-Indazole on the Antioxidant Status of Rats

Investigation of Oxidative Status of the 2-Furan-2-yl-1H-Benzimidazole in Rats

Green and One-Pot Electrochemical Synthesis of New Benzofurans Based on an ECC Mechanism

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