Investigation of Oxidative Status of the 2-Furan-2-yl-1H-Benzimidazole in Rats

Karataş, Fikret; Servi, Süleyman; Kara, Haki; Kiran, T. Ravi; Saydam, Sinan

doi:10.1007/s12011-008-8202-z

Cited by 6 publications

(5 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It also causes a significant decline in the levels of glutathione, catalase, GSH-Px, and Cu-Zn superoxide dismutase in rats [160]. The impact of 2-furan-2-yl-1H-benzimidazole on vitamins A, E, C, and Se, malondialdehyde, and glutathione peroxidase levels on rats was analysed in a study by Karatas et al [161]. The results showed that vitamins A, E, C, and Se levels were lower than the control groups, while serum MDA level and GSH-Px activity flexibly increased, depending on the injection days.…”

Section: Purposementioning

confidence: 99%

The Protective Role of Antioxidants in the Defence against ROS/RNS-Mediated Environmental Pollution

Poljšak

Fink

2014

Oxidative Medicine and Cellular Longevity

183

104

View full text Add to dashboard Cite

Overproduction of reactive oxygen and nitrogen species can result from exposure to environmental pollutants, such as ionising and nonionising radiation, ultraviolet radiation, elevated concentrations of ozone, nitrogen oxides, sulphur dioxide, cigarette smoke, asbestos, particulate matter, pesticides, dioxins and furans, polycyclic aromatic hydrocarbons, and many other compounds present in the environment. It appears that increased oxidative/nitrosative stress is often neglected mechanism by which environmental pollutants affect human health. Oxidation of and oxidative damage to cellular components and biomolecules have been suggested to be involved in the aetiology of several chronic diseases, including cancer, cardiovascular disease, cataracts, age-related macular degeneration, and aging. Several studies have demonstrated that the human body can alleviate oxidative stress using exogenous antioxidants. However, not all dietary antioxidant supplements display protective effects, for example, β-carotene for lung cancer prevention in smokers or tocopherols for photooxidative stress. In this review, we explore the increases in oxidative stress caused by exposure to environmental pollutants and the protective effects of antioxidants.

show abstract

Section: Purposementioning

confidence: 99%

The Protective Role of Antioxidants in the Defence against ROS/RNS-Mediated Environmental Pollution

Poljšak

Fink

2014

Oxidative Medicine and Cellular Longevity

183

104

View full text Add to dashboard Cite

show abstract

“…We found that MDA levels in serum, liver, and kidney increased compared with control groups at all injection times after rats had been injected with 3-(1H-pyrrol-2-yl)-1H-indazole. Increased MDA might be an indicator of lipid peroxidation, as previously suggested [27][28][29][30]. While vitamins A, E, and C levels decrease, MDA level increase in liver and kidney from the third injection can be a sign of maximum of stress.…”

Section: Discussionmentioning

confidence: 64%

“…Decreased antioxidant vitamin levels might be a result of getting more metabolic stress because vitamins A, C, E, and Se are major non-enzymatic antioxidants in the body [32]. Several previous studies have shown that increasing MDA levels occur as vitamins A, E, and C levels decrease in the serum of the rat [28,29], mainly because vitamins A and C, like α-tocopherol, prevent lipid peroxidation by trapping the free radicals. Vitamin C regenerates α-tocopherol from α-tocopheroxyl radical [33,34].…”

Section: Discussionmentioning

confidence: 99%

Effect of 3-(1H-Pyrrol-2-yl)-1H-Indazole on the Antioxidant Status of Rats

Karataş

Çöteli

Aydın

et al. 2009

Biol Trace Elem Res

Self Cite

View full text Add to dashboard Cite

The influence of injection periods of 3-(1H-pyrrol-2-yl)-1H-indazole regarding vitamins A, E, C, selenium (Se), malondialdehyde (MDA) levels, and glutathione peroxidase (GSH-Px) activity in rats has been investigated. The substance was given by subcutaneous injection at 20 mg/kg every other day for a total of 15 injections. At the end of the treatment, Se levels in serum were determined by fluorimetry, and those of vitamins A, E, C, and malondialdehyde in serum, liver, and kidney were determined by high-performance liquid chromatography. GSH-Px activities in erythrocytes were determined spectrophotometrically. Vitamins A, E, C, and Se levels were generally lower than in the controls, while GSH-Px activity at the third injection period was maximally increased, with the activities after the other injection periods being higher than in the control group. In addition, vitamins A, E, and C levels were generally lower than the control groups, while serum, liver, and kidney MDA levels gradually increased depending on injection periods. On the other hand, GSH-Px activity was higher than in the control group. Thus, the results show that while vitamins A, E, C, and Se levels decreased, MDA levels and GSH-Px activities increased after administration of 3-(1H-pyrrol-2-yl)-1H-indazole to the rats. These findings might be related to the increased amount of free radicals caused by 3-(1H-pyrrol-2-yl)-1H-indazole injection.

show abstract

“…The results of research carried out in recent years indicate that anthelmintic drugs cause oxidative stress (Karatas et al 2008, Pinlaor et al 2008, Dewa et al 2009). Ince et al (2010) demonstrated in research on rats that levamisole administered at a dose of 20 mg/kg bw for 7 days caused oxidative stress and peroxidase activity.…”

Section: Discussionmentioning

confidence: 99%

Activity of selected antioxidative enzymes in rats exposed to dimethoate and pyrantel tartrate

Barski¹,

Spodniewska²

2012

Polish Journal of Veterinary Sciences

View full text Add to dashboard Cite

This study presents the results of research concerning the effect of single and combined application of pyrantel tartrate and dimethoate on selected antioxidative enzymes: catalase (CAT), superoxide dismutase (SOD) and glutathione peroxidase (GPx), in rat erythrocytes. Pyrantel tartrate was applied twice, at a dose of 85 mg/kg bw at a two week interval, i.e. on day 14 and 28 of the experiment, orally, in a water solution with a stomach tube. Dimethoate was administered with drinking water for 28 days at a dose of 25 mg/kg bw/day. It was found that pyrantel tartrate caused only small changes in the activity of the antioxidative enzymes under analysis. Subchronic exposure of rats to dimethoate caused a significant increase in the activity of CAT, SOD and GPx in erythrocytes, indicating the existence of strong oxidative stress. In combined intoxication, no significant effects of administering pyrantel tartrate on the activity of CAT, SOD and GPx was found in animals poisoned with dimethoate. The profile of changes was similar to that observed in rats exposed only to the organophosphorus insecticide. This may indicate a lack of interaction between the compounds used in the experiment.

show abstract

Investigation of Oxidative Status of the 2-Furan-2-yl-1H-Benzimidazole in Rats

Cited by 6 publications

References 21 publications

The Protective Role of Antioxidants in the Defence against ROS/RNS-Mediated Environmental Pollution

The Protective Role of Antioxidants in the Defence against ROS/RNS-Mediated Environmental Pollution

Effect of 3-(1H-Pyrrol-2-yl)-1H-Indazole on the Antioxidant Status of Rats

Activity of selected antioxidative enzymes in rats exposed to dimethoate and pyrantel tartrate

Contact Info

Product

Resources

About