Synthesis and neurotropic properties of 2-(carboxymethylthio) derivatives of benzimidazole, benzothiazole and their ammonium salts

Synthesis of 2-Mercaptobenzimidazole and Some of its Derivatives

“…Besides the (C.H.N.S) analysis Table (3). The FT-IR spectrum of compound [9], indicated the appearance stretching band of (S-S) group at (559) cm -1 with disappearance the bond of (SH) at (2569), these bands and other are show in Table (5),While New compounds [10][11][12][13][14][15][16] were prepared by oxidation thioether to sulfone with used hydrogen peroxide. As is shown below.…”

“…Various derivatives of 2-mercapto benzimidazole have been synthesized by several investigators and have been reported to exhibit a wide range of biological activities such as anti microbial [8] antihistamine [9] neutropic [10] and analgesic [11] activities. Although a great deal of the scientific literature concerning 2-mercaptobenzimidazole is in the area of medicinal chemistry, 2-mercaptobenzimidazole is also used in non-biological application, it serve as plant growth regulators [12] and used as corrosion inhibitor for mild steel in sulfuric acid solution [13] , stainless steel in aqueous solutionsof NaCl [14] , mild steel and zinc in phosphoric acid [15,16] .…”

Mixed Ligand, Palladium(II) and Platinum(II) Complexes of Tertiary DiphosphineswithS-1H Benzo[d] Imidazole-2-yl Benzothioate

“…In 2-mercaptobenzimidazole have two N atoms and one S atom and they can independently contribute to its binding to metal 5 . 2-mercaptobenzimidazole derivatives, one of the most important derivatives of benzimidazole exhibited a wide range of importance biological activities such as antimicrobial 6 , antihistamine 7 , neutropic 8 and analgesic 9 , antiprotozoal, antiviral, and anticancer activities 10 . Metal derivatives of heterocyclic-2-thiones have shown a variety of biochemical application: as antidandruff, antifungal, antibacterial, antibiotic and in shampoos, hair creams, plant diseases and hepatitis 11 .…”

1H NMR Kinetic Investigation of the Equilibrium between the Z- and E-Isomers in a Stable Phosphorus Ylide Involving 2-Mercaptobenzimidazole

“…It has received considerable attention during last few decades as its derivatives are endowed with a variety of biological activities and have a wide range of therapeutic properties. Many derivatives possess different pharmacological and biological activities, of which the most potent are anti-ulcer [11], anti-hypertensive activity [12], anti-microbial [13], anti-inflammatory [14], anti-cancer activity [15], antihyperlipidaemic activity [16], anti-HIV [17], antisecretory [18], anthelmintic [19], antihistamine [20], neutropic [21], antimutagenic activity [22], antioxidant and anxiolytic activities [23]; recently various 2-mercaptobenzimidazole derivatives have been synthesised and screened for anti-fungal [24] and antibacterial activity [25]. In addition, some derivatives have been synthesised and examined for anti-microbial activity.…”