Synthesis of 2-Mercaptobenzimidazole and Some of its Derivatives

Abstract

The present work involved three steps: First step include synthesis of 2-mercaptobenzimidazole from reaction of o-phenylenediamine with carbon disulfide, in the second step: Alkylation of the 2-mercaptobenzimidazole with different alkyl halides or aryl to obtain thioether compounds. Third step: include oxidation of 2-mercaptobenzimidazole to disulfide, while oxidation of thioether compounds gave sulfone compounds by using hydrogen peroxide as oxidizing agent for (1-2h) with stirring at room temperature. The 2-mercaptobenzimidazole was prepared in autoclave. Structure confirmation of all prepared compounds were proved using FT-IR and elemental analysis (C.H.N.S) besides melting points.

Thiosemicarbazide Derivatives as Building Block in Synthesis of Target Heterocyclic Compounds with Their Antimicrobial Assessment

“…The antimicrobial screening of some of the synthesized compounds was carried out using Kirby–Bauer disc diffusion method . Briefly, 100 μL of the tested bacteria/fungi were grown in 10 μL of fresh media until they reached a count of approximately 108 cells per mL for bacteria or 105 cells per mL for fungi . 100 μL of microbial suspension was spread onto agar plates corresponding to the broth in which they were maintained.…”

Synthesis and antidiabetic evaluation of benzimidazole‐tethered 1,2,3‐triazoles

“…2-(Methylthio)-1H-benzimidazole 1b was synthesized by a two-step procedure according to an earlier reported method. [35] In a 250-ml round-bottom flask, o-phenylenediamine (2.0 g) was dissolved in absolute ethanol (50 ml) and then carbon disulfide (14 ml) was added. The N-substituted 2-bromoacetamides 3a-i were synthesized by an earlier reported method.…”

Synthesis and characterization complexes of bis (2-mercaptobenzimidazole) mercury (II) with transition metal (Ni (II), Pd (II), and Pt (II))

“…The spectra of the ligand exhibited band at 1514 cm -1 due to the V(C=N) group of the ligand and when the complexes were formed this spectra were shifted to higher or lower frequency in the range (1622-1490)cm -1 which indicate that the ligand was bonded to the metal ion through N atom of V(C=N)group (Kennedy et al, 1972, Mohammed et al, 2013, Anandarajagopal et al, 2010, Ganesh et al, 2011, Akira et al, 1970, Rehman et al, 2013, also the ligand showed band at (736)cm -1 due to the V(C-S) group of the ligand and this band was shifted to higher or lower frequency in the range (742-725)cm -1 during the complexes which indicate that the ligand was bonded to the metal ion through sulphur atom (Zora et al, 2002, Butrus et al, 2012, Irshad et al,2010, Khullar et al,1975 .The infrared spectra of the prepared complexes show band in the range (451-412) cm -1 , which are attributed to V (M-N) . On the other hand, it has been observed that in the spectra of all compounds, the bands at (310-290) cm -1 were assigned to V (Hg-S) (Carlo et al, 1977, Musa, 1998, Awaz, 2015.…”