Synthesis and molecular docking study of some 5,6-dichloro-2-cyclopropyl-1 H -benzimidazole derivatives bearing triazole, oxadiazole, and imine functionalities as potent inhibitors of urease

Synthesis and In Vitro Urease Inhibition of Some Novel Benzimidazole‐based Hydrazones

“…PO 4 3− anion has a significant role as hydrogen bond acceptor in the active region of urease enzyme. Recently reported in silico docking results showed that “the H‐bonding is more important than other factors in urease inhibition mechanism .”…”

“…Benzimidazoles are clearly known as significant chemical species with a wide range of biological activities including antioxidant , anticancer , antimicrobial , enzyme inhibition , and great potential. Benzimidazole and its derivatives have an important role in the field of medicine.…”

“…Although all the positions of the benzimidazole ring can be substituted with a variety of chemical entities, most of the biologically active benzimidazole derivatives, obtained up to now, have functional groups at 1‐, 2‐, and/or 5‐ (or 6‐) positions . Literature survey reveals that 5,6‐dichlorobenzimidazole derivatives are very important for their pharmacological activities like antitumor, antioxidant, antiurease, antiparasitic, and antilipase (Scheme ) .…”

“…Because of these properties, hydrazones are widely used in medicinal chemistry . Recently, some benzimidazole‐based hydrazones have been reported as potent urease inhibitors .…”

Microwave-assisted synthesis of some nitro-benzimidazoles and their salicyl and isatin Schiff bases

“…In the design of new bioactive compounds, the synthesis of hybrid molecules containing different pharmacophore groups is a useful strategy [26][27][28][29][30][31][32][33][34][35][36][37][38][39][40][41][42]. In the present study, we have synthesized some 5(6)-nitro benzimidazoles and their salicyl and isatin Schiff bases, which are important pharmacophores in drug design, by using microwave irradiation.…”