Synthesis and <i>in Vitro</i> Antiproliferative Evaluation of Novel Hybrids from 1,3,4-Thiadiazole and Benzisoselenazolone

Development and Therapeutic Potential of Selenazo Compounds

“…It is noticeable that the inclusion of two methoxide groups in the resveratrol moiety resulted in an increase in the level of apoptosis and the G 2 /M cell cycle arrest and also exhibited the best TrxR inhibitory activity. On the other hand, the incorporation of other versatile bioactive nucleus such as 1,2,4-triazole (I-4 in Figure 1) 36 or 1,3,4-thiadiazole (I-5 in Figure 1) 37,38 reinforced the idea that the nature of the functional groups on the triazole or thiadiazole rings is determinant for the antiproliferative activity and selectivity. For example, among the triazole compounds, the aliphatic chains were the most active against SMMC-7721 cells while in the thiadiazoles, the substituent groups over the phenyl ring were of vital importance for modulating the antitumor activity.…”

Nanoparticles in Cancer Diagnosis and Treatment

“…Despite their origins as an antioxidant, selenium-based medications like ebselen (Figure 4) have demonstrated potential anticancer action against breast, liver, and colon cancer cells. In Phase I clinical studies for the treatment of non-small cell lung cancer, ethaselen, a modified version of ebselen, has demonstrated better solubility [82,86]. According to studies, selenium can prevent cancer by preventing DNA damage brought on by the production of adducts caused by dimethylbenz(a) anthracene, which is a factor in the development of breast, colon, and liver cancers [87].…”