Nanoparticles in Cancer Diagnosis and Treatment

Abstract

The use of tailored medication delivery in cancer treatment has the potential to increase efficacy while decreasing unfavourable side effects. For researchers looking to improve clinical outcomes, chemotherapy for cancer continues to be the most challenging topic. Cancer is one of the worst illnesses despite the limits of current cancer therapies. New anticancer medications are therefore required to treat cancer. Nanotechnology has revolutionized medical research with new and improved materials for biomedical applications, with a particular focus on therapy and diagnostics. In cancer research, the application of metal nanoparticles as substitute chemotherapy drugs is growing. Metals exhibit inherent or surface-induced anticancer properties, making metallic nanoparticles extremely useful. The development of metal nanoparticles is proceeding rapidly and in many directions, offering alternative therapeutic strategies and improving outcomes for many cancer treatments. This review aimed to present the most commonly used nanoparticles for cancer applications.

Nanoparticle-Mediated Radiotherapy: Unraveling Dose Enhancement and Apoptotic Responses in Cancer and Normal Cell Lines

“…Regarding the AuNPs incubation and treatment results, it is apparent that the cell survival rate decreases significantly for the cancer cell lines with AuNPs compared to the control cells, indicating severe cell damage to cancer cells, and enhanced localized dose deposition. On the other hand, very low to no radiation enhancement effect after the AuNPs use was observed on the healthy/noncancerous cells (Figures 4 and 5), a fact that experimentally verifies the AuNPs selectively targeting on cancer cells while sparing healthy tissues [48]. This also attests to the enhanced permeability and retention (EPR) effect as well as the low systemic clearance of cancer cells compared to the low permeability of normal cells [49,50].…”

Potential Biomedical Applications of Terbium-Based Nanoparticles (TbNPs): A Review on Recent Advancement

“…In addition, very few significant studies indicate the potential toxicity of TbNPs in biological systems. In the dynamic realm of biomedical research, TbNPs have emerged as promising contenders for a plethora of applications, ranging from targeted drug delivery to advanced imaging modalities. , However, as we navigate the exciting potential of TbNPs in the biomedical landscape, it becomes imperative to scrutinize and understand the subtle toxicological concerns that may accompany their integration into biological systems. , Drawing from the convergence of nanotechnology and medicine, we delve into the multifaceted interactions between TbNPs and biological entities, focusing on ensuring these NPs ’ safety and efficacy in the intricate milieu of the human body. The unique electronic and magnetic properties of TbNPs, which make them attractive for various applications, also raise questions regarding their potential adverse effects on living organisms .…”

Chemotherapeutic Potential of AgNP Orchestrated Semecarpus anacardium Nut Extracts Against Ovarian Cancer Cell Line, PA-1

“…Rigorous in vivo studies employing animal models are pivotal for validating the efficacy and safety of AgNPs in a more complex biological milieu, providing crucial insights for translational research. Further research endeavors are essential to unlock the full therapeutic potential of AgNPs while mitigating associated risks, paving the way for their integration into cancer treatment strategies [76].…”