Synthesis and investigation of some bisbenzimidazoloquinazolines

Functionalized 4-methyl-5-phenylthiazole and 1,3-bis(4'-methyl-5'-phenylthiazol-2'-yl)benzene. Approaching thiazole macrocycles

“…In 10-12 h the precipitate was drained, washed with 5% water solution of NaHCO 3 and water (3×50 ml), then air-dried, and 2.1 g (80%) of bisthiazol 10 was obtained, mp 177-179°С (EtOH). IR (vaseline, cm (14). To the solution of thiourea (0.31 g, 40 mmol) in 40 ml of acetonitrile the dichloride 13 (0.51 g, 1.00 mmol) solution in 10 ml chloroform was added.…”

Macrocycles, derivatives of nitrogen-containing heterocycles 3. Synthesis of di(imidazo[1,5-a]quinoxalina)-2(1,3)-benzadithiacycloalkaphanes

“…Het stands for thienyl, 10,11 pyrazolyl, 12 imidazolyl, 12,13 thiazol yl, 13, 14 1,3,4 oxadiazolyl, 15 1,3,4 thiadiazolyl, 13 1,2,4 triazol yl, 16-18 benzoxazolyl, 19,20 indolyl 21 , benzimidazolyl, 22-24 1,2,4 triazolo[3,2 a]isoindolyl, 25 1,2,4 triazolo[3,2 c]quinazoline 18 ( The presence in meta positions of the benzene ring of two heterocyclic fragments rigidly oriented with respect to each other makes 1,3 dihetarylbenzenes 1 very interesting as both the bidentate chelating agents and the macrocycle precursors. When appropriate and easily transformable functional groups are present on the heterocyclic rings, compounds 1 can be used for construction of various types of heteromacrocyclic systems including those containing a disulfide fragment, which is of significant interest for organic and bioorganic chemistry.…”