Synthesis and investigation of certain androstane derivatives of 5-fluorouracil

Volovel'skii, L. N.; Rastrepina, I. A.; Popova, N. V.; Koryukina, V. N.; Zidermane, A. A.; Dauvarte, A. Zh.

doi:10.1007/bf01148631

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Through Spacer Groupsscatalysts2

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1997

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“…These authors found that on cathodic reduction 3α-derivatives gave a dimer, 6β,6β‘-dinitro-3α,3α‘-cholesta 4,4‘-dimer, as the major product via a one-electron process. The synthesis and antileukemic activity of two androstane moieties linked by 5-fluorouracil has been described by Volovelskii and co-workers . Both the 5α- and 5β-isomers of 3-oxoandrostan-17-ol ( 19 and 53 ) are syn dimerized to symmetrical N -methylpyrroles ( 51 and 54 ) in a Fisher-type reaction by treatment with N , N ‘-dimethylhydrazine in the presence of a weak acid catalyst (Scheme ) …”

Section: 12 Through Spacer Groupscatalystsmentioning

confidence: 99%

“…The synthesis and antileukemic activity of two androstane moieties linked by 5-fluorouracil has been described by Volovelskii and co-workers. 53 Both the 5R-and 5β-isomers of 3-oxoandrostan-17-ol (19 and 53) are syn dimerized to symmetrical N-methylpyrroles (51 and 54) in a Fisher-type reaction by treatment with N,N′-dimethylhydrazine in the presence of a weak acid catalyst (Scheme 15). 54…”

Section: Through Spacer Groupsscatalystsmentioning

confidence: 99%

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