Dimeric and Oligomeric Steroids

Steroidal Dimer by001 Inhibits Proliferation and Migration of Esophageal Cancer Cells via Multiple Mechanisms

“…cephalostatin I, ritterazines A, and crellastatin A) and show potent antiproliferative activities against human cancer cell lines [9,10]. Inspired by the structural novelty and promising bioactivities of steroidal dimers, a large number of new steroidal dimers have been synthesized and assessed for their biological potential [11][12][13]. However, their detailed mechanisms of action are less studied.…”

Spectroscopic methods and theoretical studies of bromoacetic substituted derivatives of bile acids

“…[11][12][13][14][15][16][17][18] Moreover, the unique structural elements of bile acids are very important in the study of molecular recognition, host-guest chemistry and biomimetic chemistry. They also play a very significant role in supramolecular chemistry and as drugs in pharmacology.…”

“…Bile acids themselves have been used as building blocks for the design and construction of new molecular receptors that are capable to recognize guest molecules of diverse chemical nature. [13][14][15][16] Bile acid dimers can be used for the synthesis of macrocyclic compounds as artificial receptors. [19][20][21][22][23] Some derivatives of bile acids are very good organogelators.…”

Synthesis of two isomers of 3-amino-7α-12α-dihydroxy-5β-cholanic acid

“…Cholic acid, and its deoxy analogues, have been variously exploited for the construction of synthetic receptors, novel amphiphiles, and scaffolds for the assembly of combinatorial libraries (4)(5)(6). In all these applications, there are significant advantages to the replacement of hydroxyl by amino functionality.…”