Synthesis and Insecticidal Activity of Enzyme-Triggered Functionalized Hollow Mesoporous Silica for Controlled Release

Kaziem, Amir E.; Gao, Yunhao; He, Shun; Li, Jianhong

doi:10.1021/acs.jafc.7b02560

Cited by 115 publications

(84 citation statements)

References 59 publications

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“…To release chemical substances in a controlled manner is a key technology in food, agriculture, biomedicine, cosmetics, personal care, and beauty industries . Controlled release can often avoid harmful high concentrations and make the chemicals available for a prolong period of time.…”

Section: Introductionmentioning

confidence: 99%

Nanocarriers and Their Loading Strategies

Wang

Cheng

et al. 2018

Adv Healthcare Materials

172

141

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Nanocarriers are of paramount significance for drug delivery and nanomedicine technology. Given the imperfect systems and nonideal therapeutic effects, there are works to be done in synthesis as much as in biological studies, if not more so. Building the foundation of synthesis would offer more tools and deeper insights for exploring the biological systems with extreme complexity. This review aims at a broad‐scope summary and classification of nanocarriers for drug delivery, with focus on the synthetic strategy and structural implications. The nanocarriers are divided into four categories according to the loading principle: molecular‐level loading, surface loading, matrix loading, and cavity loading systems. Making comparisons across diverse nanocarrier systems would make it easier to see the fundamental characteristics, from where the weakness can be addressed and the strengths combined. The systematic comparisons may also inspire new ideas and methods.

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Section: Introductionmentioning

confidence: 99%

Nanocarriers and Their Loading Strategies

Wang

Cheng

et al. 2018

Adv Healthcare Materials

172

141

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“…1 Several inorganic supports were used for the immobilization of enzymes, such as gold, 5 silica, 6 magnetic nanoparticles, 7,8 and mesoporous silicas. 9 Anyway, when the above materials are used in biomedical applications, important issues have to be taken into account, such as the interactions between the enzyme and the inorganic supports as well as their bio-absorption capacity. On this respect, polymers, which are characterized by a relevant versatility and a good biocompatibility and biodegradability can overcome these drawbacks.…”

mentioning

confidence: 99%

Encapsulated functionalized stereocomplex PLA particles: An effective system to support mucolytic enzymes

Boi

Dellacasa

Bianchini

et al. 2019

Colloids and Surfaces B: Biointerfaces

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In this work, the preparation of a novel enzyme carrier based on a polymer multicomponent system was assessed. Indeed, the design of the above system considered several issues that are the need of applying a biodegradable polymer carrier, characterized by a nanometric dimension, thus suitable to diffuse into the dense mucus structure, with functionalities capable of interacting/reacting with enzymes but resistant to enzymatic degradation. The particles were prepared from solutions containing equimolar amount of highmolecular-weight poly(L-lactide) (PLLA) and poly(D-lactide) (PDLA) and by applying the nanoprecipitation method. Dynamic Light Scattering (DLS) measurements allowed to establish the optimal preparation conditions to obtain polymer particles characterized by diameters lower than 1 μm, which dimensions were confirmed by Field Emission Scanning Electron Microscope (FE-SEM) analysis. In order to produce surface functionalization, necessary for anchoring enzymes, the stereocomplexed particles, whose structuration was confirmed by Differential Scanning Calorimetry (DSC) measurements, underwent an amminolysis reaction by using a diamine as reactant. The treated particles were characterized by means of FE-SEM, Fourier-Transform Infrared Spectroscopy (FTIR), DLS and zeta potential measurements and their characteristics were compared with those of the neat PLLA/PDLA particles. The degree of functionalization turned out to depend on the applied conditions, it increasing by enhancing the reaction time. The activity of enzymes, i.e. papain and alginate lyase, anchored to the particles , was evaluated by Quartz Crystal Microbalance (QCM) and UV measurements.Moreover, with the aim at exploiting the material for an inhalation administration, a method to encapsulate the enzyme-particles systems was assessed. Conversely to free enzymes, the developed systems were found to be capable of diminishing the viscosity of two hydrogels, ad hoc prepared and based on the main constituents of the real mucus.

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“…Using an enzyme responding to control drug release can improve therapeutic efficiency and reduce damage to the human body. α-CD can be enzymatically hydrolyzed by α-amylase, which consequently is used as a gatekeeper of enzyme-responsive drug carriers [137].…”

Section: Response To Enzymesmentioning

confidence: 99%

Hollow structures as drug carriers: Recognition, response, and release

Zhao

Yang

et al. 2021

Nano Res.

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Hollow structures have demonstrated great potential in drug delivery owing to their privileged structure, such as high surface-to-volume ratio, low density, large cavities, and hierarchical pores. In this review, we provide a comprehensive overview of hollow structured materials applied in targeting recognition, smart response, and drug release, and we have addressed the possible chemical factors and reactions in these three processes. The advantages of hollow nanostructures are summarized as follows: hollow cavity contributes to large loading capacity; a tailored structure helps controllable drug release; variable compounds adapt to flexible application; surface modification facilitates smart responsive release. Especially, because the multiple physical barriers and chemical interactions can be induced by multishells, hollow multishelled structure is considered as a promising material with unique loading and releasing properties. Finally, we conclude this review with some perspectives on the future research and development of the hollow structures as drug carriers.

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Synthesis and Insecticidal Activity of Enzyme-Triggered Functionalized Hollow Mesoporous Silica for Controlled Release

Cited by 115 publications

References 59 publications

Nanocarriers and Their Loading Strategies

Nanocarriers and Their Loading Strategies

Encapsulated functionalized stereocomplex PLA particles: An effective system to support mucolytic enzymes

Hollow structures as drug carriers: Recognition, response, and release

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