Synthesis and in vitro Evaluation of 1,2,3-triazole-4-chloromethylcoumarins with Antioxidant Activity

In this paper, we report an efficient and versatile methodology for the synthesis of a series of novel heteroaryl‐1,2,3‐triazoles connected to 4‐methylcoumarin (4‐methyl‐2H‐chromen‐2‐one) via oxymethylene linker. The desired molecules were accessed by both two‐step synthesis and the one‐pot copper catalyzed cycloaddition reaction of heteroaromatic azides with coumarin containing acetylenes. The developed protocol was found to be facile and effective for preparing a series of novel heteroaryl‐1,2,3‐triazole‐coumarin conjugates in excellent yields. Practical utility of one‐pot protocol has been confirmed by the successful gram‐scale synthesis of 1,3‐Dimethyl‐6‐(4‐[([4‐methyl‐2‐oxo‐2H‐chromen‐7‐yl]oxy)methyl]‐1H‐1,2,3‐triazol‐1‐yl)pyrimidine‐2,4(1H,3H)‐dione.

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Design and the synthesis of 1‐heteroaryl‐1,2,3‐triazoles connected to coumarins via ether linker

Joy

Беляев

Beryozkina

et al. 2020

Journal of Heterocyclic Chem

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Antioxidant and anti-sickling activity of glucal-based triazoles compounds – An in vitro and in silico study

Veloso

Shamim

Lamarrey

et al. 2021

Bioorganic Chemistry

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Design, Synthesis, and Biological Activity of New Bis-1,2,3-triazole Derivatives Bearing Thiophene-Chalcone Moiety

et al. 2019

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Synthesis and in vitro Evaluation of 1,2,3-triazole-4-chloromethylcoumarins with Antioxidant Activity

Cited by 3 publications

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Design and the synthesis of 1‐heteroaryl‐1,2,3‐triazoles connected to coumarins via ether linker

Design and the synthesis of 1‐heteroaryl‐1,2,3‐triazoles connected to coumarins via ether linker

Antioxidant and anti-sickling activity of glucal-based triazoles compounds – An in vitro and in silico study

Design, Synthesis, and Biological Activity of New Bis-1,2,3-triazole Derivatives Bearing Thiophene-Chalcone Moiety

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