This work focuses on the synthesis of undoped and doped lanthanum oxide nanoparticles (La
2
O
3
NPs) by a simple co-precipitation method for the catalytic reduction of 4-nitrophenol (4-NP) using NaBH
4
as a reducing agent. Their optical properties, morphologies, structure, chemical compositions and electronic properties were carefully characterized by XRD, FTIR, SEM, TEM, PL and UV–visible absorption spectroscopy. The SEM and TEM images showed various shape morphologies and sizes of the particles. The XRD pattern revealed a polycrystalline nature with the hexagonal structure of the La
2
O
3
NPs. The synthesized undoped and doped La
2
O
3
NPs were also employed as catalysts for the reduction of 4-nitrophenol, it shows that the doped (Sm
3+
, Gd
3+
and Hf
3+
) La
2
O
3
NPs provided better catalytic activity than the undoped La
2
O
3
NPs. Moreover, Hf
3+
doped La
2
O
3
NPs exhibited an enhanced catalytic activity for the reduction of 4-nitrophenol to 4-aminophenol in 90 min. The catalytic conversion was studied by UV–vis spectroscopy with high reduction rate (k = 2.048 min
−1
). The applications of the present study may utilize in the removal of toxic pollutants in a cleaning of environmental pollution as well as in industrial applications.
A convenient synthesis of novel prototypes containing the two pharmacophores of chromene and 1,2,3-triazole in a single molecular backbone, were evaluated againstMycobacterium tuberculosisH37Rv strain.
Coumarin-based 1,4-disubstituted 1,2,3-triazole derivatives were synthesized using a highly efficient, ecofriendly protocol via a copper(I)-catalyzed click reaction between various substituted arylazides and terminal alkynes. The synthetic route was easy to access and gave excellent yields under microwave irradiation conditions compared to the conventional heating route. The structures of all the compounds were characterized by IR, 1 H NMR, 13 C NMR spectroscopy and mass spectrometry. All the synthesized compounds were screened for their in vitro antimicrobial, antioxidant and anti-inflammatory activities; among all compounds, 8a, 8j, 8k and 8l exhibited better results with respect to standard drugs.Furthermore, molecular docking studies have been carried out with PDB IDs 2VCX (anti-inflammatory), 3VXI (antioxidant), 4GEE (antimicrobial) and 2XFH (antifungal) using the Glide module of the Schrödinger suite. The final compounds 8d, 8e, 8h, and 8k showed the highest hydrogen bond interactions with His-88 and Val-191 proteins and with water in all the proteins.
A series of 2 0 -substituted-3 0 -methylspiro[cyclohexane-1,7 0 -furo[3,2-g]chroman]-5 0 (7 0 H)-one, 5a-i and 7au have been synthesized using an eco-friendly approach to attain good yields in a shorter reaction time. The structures of novel compounds were characterized by IR, 1 H NMR, 13 C NMR and mass spectrometry analysis. All the synthesized compounds were evaluated for their biological activity. Compounds 5a, 5b, 5c, 5d, 5e, 7g, 7h, 7j, 7l, 7n and 7q were found to have better anti-inflammatory activity in the albumin denaturation technique. All compounds exhibited good antioxidant activity by DPPH radical scavenging assay and most compounds showed activity in a hydrogen peroxide assay. Molecular docking scores as well biological assays results suggested that compound 7h has better anti-inflammatory activity among the synthesized compounds.Scheme 2 Synthesis of compounds 7a-u.25712 | RSC Adv., 2017, 7, 25710-25724This journal is
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