Synthesis and in vitro evaluation of carboxymethyl starch–chitosan nanoparticles as drug delivery system to the colon

Saboktakin, Mohammad Reza; Tabatabaie, Roya M.; Maharramov, Abel; Рамазанов, М. А.

doi:10.1016/j.ijbiomac.2010.10.005

Cited by 103 publications

(31 citation statements)

References 16 publications

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“…Therefore, it is generally introduced in human diets with wheat, corn, potatoes, cassava, and rice. Starch-based products are the most frequently used biomaterials in food, papermaking, packaging industries, beverages, and textiles as well as in medicine, pharmacy, and cosmetic (Balmayor et al, 2009;Saboktakin et al, 2011;Salgado et al, 2007).…”

Section: Starchmentioning

confidence: 99%

Halloysite ‐Based Bionanocomposites

Lazzara

Massaro

Milioto

et al. 2017

Handbook of Composites From Renewable Materials

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Scientific research has been invigorated by a new class of biodegradable materials as alternatives to polymers derived from fossils. Such biomaterials can also offer economic advantages because they are derived from renewable resources. Several biopolymers (gelatin, chitin, chitosan, starch, pectin, cellulose and its modified versions, etc.) have been exploited to produce films and formulations. Their use is limited because of fast degradation, predominant hydrophilic character, and, in some cases, unsatisfactory mechanical properties. However, the properties of these polymers can be improved by using inorganic fillers such as additives. Halloysite nanotube is a promising green filler for this purpose.

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Section: Starchmentioning

confidence: 99%

Halloysite ‐Based Bionanocomposites

Lazzara

Massaro

Milioto

et al. 2017

Handbook of Composites From Renewable Materials

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“…Several types of hydrogels have been prepared by noncovalent crosslinking, incorporating anionic polymers, such as carboxymethylcellulose, carboxymethylated starch or alginic acid, on cationic polymers like chitosan (polyelectrolyte complexation) [5][6][7][8][9][10]. Also, the same anionic polymers have been used with CaCl 2 (ionotropic gelation) [11,12] or a mix of polymers with the salt [13,14].…”

Section: Introductionmentioning

confidence: 99%

Polyelectrolyte Complexation versus Ionotropic Gelation for Chitosan-Based Hydrogels with Carboxymethylcellulose, Carboxymethyl Starch, and Alginic Acid

Henao

Delgado

Contreras

et al. 2018

International Journal of Chemical Engineering

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e preparation of gels by charge interaction methods has been extensively studied, but it is not yet clear how these methods influence gel characteristics. e objective of this work was to study differences in morphology and surface charge of hydrogels prepared by ionotropic gelation, polyelectrolyte complexation, and a combination of both methods. us, the anionic charge was provided by carboxymethylcellulose (CMC), carboxymethylated starch (CMS), and alginic acid (AA); calcium chloride (CaCl 2 ) and chitosan (CS) were used for the ionotropic gelation and polyelectrolyte complexation, respectively. ose materials are commercially available, have low toxicity, and are widely used in the area. ese compounds interact through physical crosslinks, which are affected by physical changes of the medium. Our results showed that these two methods produced changes in the morphology of the hydrogels. CMC gels exhibited larger pores in the presence of CaCl 2 . In polyelectrolyte complexation, CMS produced an increased agglomeration of particles, while the addition of CaCl 2 to AA generated dispersed particles of size in the order of millimeters. Mixing both ionotropic gelation and polyelectrolyte complexation methods yielded gels of varied charge (568 mV for CMC, 502 mV for CMS, and 1713 mV for AA). FTIR spectra of the hydrogels showed interactions between the different polymeric compounds, being the greatest changes between 1250 and 1600 cm −1 , due possibly to the replacement of Na by Ca at crosslinking points. erefore, the method of gel preparation employed had a major influence on the size and pore distribution, parameters which in turn influence encapsulation and drug delivery in these systems.

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“…Mucoadhesive nanocarriers offer strategy by combining targeted drug delivery and enhanced anticancer ability in one entity [8][9][10]. The targeted therapy effect is achieved through preventing the drug release in stomach and triggering release at the target site [8,11].…”

Section: Introductionmentioning

confidence: 99%

“…The targeted therapy effect is achieved through preventing the drug release in stomach and triggering release at the target site [8,11]. The specific surface characteristics of nanocarriers can increase the contact between loaded drug and intestinal mucosa and enhance cellular uptake of formulation [3,12,13].…”

Section: Introductionmentioning

confidence: 99%