Synthesis and in vitro cytotoxicity evaluation of ruthenium polypyridyl-sensitized paramagnetic titania nanoparticles for photodynamic therapy

Abstract

We demonstrate the effective cytotoxic properties of a dye-sensitized metal oxide in an in vitro model of a human lung cancer cell line (A549 cells) upon light irradiation, where a type I mechanism photo-dynamic therapy is realized exclusively.

Advanced Biomedical Applications of Reactive Oxygen Species-Based Nanomaterials in Lung Cancer

“…Under 532 nm light illumination, the excellent ROS production is observed while the singlet oxygen generation is negligible. The advantages of the dyed NPs might be a significant increase in ROS production and it’s efficient action against low-oxygen cancerous cells ( Sakr et al, 2016 ). NPs can destroy the endogenous antioxidant defense system by consuming intracellular antioxidant substances.…”

Precise cell behaviors manipulation through light-responsive nano-regulators: recent advance and perspective

“…For instance, light responsive polymers which conjugate different light-responsive photochromic moieties as azobenzene, coumarin, spiropyran O-nitrobenzyl (ONB), 4-bromo-7-hydroxycoumarin (BHC), and 2-diazo-1,2-naphthoquinone (DNQ) in organic polymer structures have promoted the photoinduced transformations and photocleavage reactions 48-52. The organic polymers could also encapsulate photo-responsive molecules like chlorine e6 (Ce6), Br-substituted boron-dipyrromethene (BODIPY) or metal complexes for good colloidal stability and controlled photodynamic therapy 53-55.…”

Cyclometalated IrIII Complexes as Mitochondria‐Targeted Photodynamic Anticancer Agents

“…[9][10][11] Ru II complexes are regarded as the successors of the Pt-based complexes for traditional chemotherapy and have been exploited as photosensitizers for PDT. [12][13][14][15][16][17][18] Gasser and coworkers have carried out abundant fruitful works aiming at the Ru II -based photosensitizers for PDT and traditional chemotherapy. [19][20][21][22][23] Meanwhile, besides platinum and ruthenium complexes, a large number of other metal complexes have been studied in the field of chemotherapy [24][25][26][27][28][29][30][31][32][33][34][35] and PDT.…”

“…Among all kinds of the photosensitizers exploited for PDT agents, metal complexes have received great interest for their easily tunable photophysical and photochemical properties by using different ligands . Ru II complexes are regarded as the successors of the Pt‐based complexes for traditional chemotherapy and have been exploited as photosensitizers for PDT . Gasser and co‐workers have carried out abundant fruitful works aiming at the Ru II ‐based photosensitizers for PDT and traditional chemotherapy .…”