Precise cell behaviors manipulation through light-responsive nano-regulators: recent advance and perspective

Thang, Do Cong; Wang, Zhimin; Lü, Xiaoling; Xing, Bengang

doi:10.7150/thno.33888

Cited by 38 publications

(30 citation statements)

References 275 publications

(283 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Bacterial ghosts keep cellular morphology similar to native bacteria, where the entire surface structures including adhesins, membrane proteins, lipopolysaccharides, and the peptidoglycan layer are preserved [250]. Drug carriers can be also obtained from bacterial outer membrane vesicles [251]. Gujrati et al [252] developed bioengineered bacteria vesicles for both contrast enhancement in photoacoustic imaging and PTT.…”

Section: Bacteria-based Drug Carriersmentioning

confidence: 99%

Optically responsive delivery platforms: from the design considerations to biomedical applications

et al. 2020

View full text Add to dashboard Cite

Drug carriers with intelligent functions are powerful therapeutic and diagnostic platforms in curing various diseases such as malignant neoplasms. These functions include the remote noninvasive activation of drug using physical impacts, e.g. light exposure. Combination of different therapeutic modalities (chemotherapy, photodynamic therapy, and so forth) with light-responsive carriers enables promising synergetic effect in tumour treatment. The main goal of this review article is to provide the state of the art on light-sensitive delivery systems with the identification of future directions and their implementation in tumour treatment. In particular, this article reviews the general information on the physical and chemical fundamental mechanisms of interaction between light and carrier systems (e.g. plasmonic and dielectric nanoparticles), the design of optically responsive drug carriers (plain and composite), and the mechanisms of light-driven controlled release of bioactive compounds in biological environment. The special focus is dedicated to the most recent advances in optically responsive bioinspired drug vehicles.

show abstract

Section: Bacteria-based Drug Carriersmentioning

confidence: 99%

Optically responsive delivery platforms: from the design considerations to biomedical applications

et al. 2020

View full text Add to dashboard Cite

show abstract

“…It has also found application in the design of drug carrier systems. The lightresponsive structure can easily be regulated, and it has low invasiveness (Thang et al 2019). Its mechanism of activity is based on the alteration of the light-sensitive molecules when stimulated by light, thus enabling the release of the encapsulated or conjugated drug (Linsley and Wu 2017).…”

Section: Introductionmentioning

confidence: 99%

Nanoparticles as therapeutic options for treating multidrug-resistant bacteria: research progress, challenges, and prospects

Ifeanyi

Nweze

2021

World J Microbiol Biotechnol

166

View full text Add to dashboard Cite

Resistance to antimicrobial agents has been alarming in recent years and poses a huge public health threat globally according to the WHO. The increase in morbidity and mortality resulting from microbial infections has been attributed to the emergence of multidrug-resistant microbes. Associated with the increase in multidrug resistance is the lack of new and effective antimicrobials. This has led to global initiatives to identify novel and more effective antimicrobial agents in addition to discovering novel and effective drug delivery and targeting methods. The use of nanoparticles as novel biomaterials to fully achieve this feat is currently gaining global attention. Nanoparticles could become an indispensable viable therapeutic option for treating drug-resistant infections. Of all the nanoparticles, the metals and metal oxide nanoparticles appear to offer the most promise and have attracted tremendous interest from many researchers. Moreover, the use of nanomaterials in photothermal therapy has received considerable attention over the years. This review provides current insight on antimicrobial resistance as well as the mechanisms of nanoparticle antibacterial activity. It offers an in-depth review of all the recent findings in the use of nanomaterials as agents against multi-resistant pathogenic bacteria. Also, nanomaterials that can respond to light stimuli (photothermal therapy) to kill microbes and facilitate enhanced drug delivery and release are discussed. Moreover, the synergistic interactions of nanoparticles with antibiotics and other nanomaterials, microbial adaptation strategies to nanoparticles, current challenges, and future prospects were extensively discussed.

show abstract

“…Light with different wavelength from visible (vis) to NIR is a widespread external physical stimulus used in the biomedicine because of its intrinsic noninvasive performance and ability to modulate the exposure location and dose without interference of individual difference 205–208 . In recent decades, numerous researchers have made great efforts to exploit light‐responsive smart materials to achieve targeting drug release for cancer treatment, such as vis‐responsive composite biomaterials and NIR‐responsive photothermal biomaterials 209,210 …”

Section: Exogenous‐triggered Smart Materialsmentioning

confidence: 99%

Smart materials for drug delivery and cancer therapy

Yang

Zeng

Huang

et al. 2020

VIEW

119

View full text Add to dashboard Cite

Until now, enormous smart materials have been engineered with endogenous stimulators such as pH, reactive oxygen species, glutathione, hypoxia and enzyme, or exogenous stimulators such as temperature, light, ultrasound, radiation, and magnetic field in drug delivery. As footstone of stimuli‐responsive nanocarriers, endogenous/exogenous responsive smart materials possess many properties, such as responding ability to specific triggers, controlled drug release, long blood circulation, increased tumor accumulation, “ON‐OFF” switch activities, enhanced diagnostic accuracy, and therapeutic efficacy. Smart materials have attracted considerable attention because they provide likelihood strategy for individualized and comprehensive therapy. In this review, significant research achievements of smart materials responsive to different triggers including their synthesis and formulation mechanism, responsive mechanism, applications, multiple functions are summarized and discussed separately. We primarily focus on the studies in the past few years (2017‐2020). The current situation and remaining challenges of stimuli‐sensitive materials‐based nanocarriers for clinical translation are discussed rationally at the end. It is hope that this timely and overall review would provide some helpful information for researchers in this field.

show abstract

Precise cell behaviors manipulation through light-responsive nano-regulators: recent advance and perspective

Cited by 38 publications

References 275 publications

Optically responsive delivery platforms: from the design considerations to biomedical applications

Optically responsive delivery platforms: from the design considerations to biomedical applications

Nanoparticles as therapeutic options for treating multidrug-resistant bacteria: research progress, challenges, and prospects

Smart materials for drug delivery and cancer therapy

Contact Info

Product

Resources

About