Synthesis and in vitro antitumor activity of new series of benzothiazole and pyrimido[2,1-b]benzothiazole derivatives

Evaluation of 6-chloro-N-[3,4-disubstituted-1,3-thiazol-2(3H)-ylidene]-1,3-benzothiazol-2-amine Using Drug Design Concept for Their Targeted Activity Against Colon Cancer Cell Lines HCT-116, HCT15, and HT29

“…Some new studies report protein overexpression in 35–49% of total cases [8–12]. The wide range of EFFR expression in colorectal cancer is reported in many studies, and EGFR expression as a prognostic indicator may be related to the methodology used to detect EGFR [13–15]. Therefore, the design of inhibitors that target EFFR-TK is a better approach to new drug development (Figure 1).…”

Design and synthesis of benzothiazole/thiophene-4H-chromene hybrids

“…the resulting product was decreased. The structure of the product 4a was conrmed by 1 H, 13 C NMR and HRMS spectra (Scheme 2). A plausible reaction mechanism for 4a has been proposed and is illustrated in Scheme 3.…”

“…A wide range of benzothiazole derivatives were found to possess anticancer activity, and there were several reports, where the benzothiazole nucleus was modied in order to improve their antitumor activities. [12][13][14][15][16][17][18][19][20] The anticancer activity of these molecules may be attributed to the formation of reactive intermediates that can bind covalently to DNA. 21 Modications on the benzothiazole nucleus have resulted in a large number of hybrids having diverse pharmacological activities.…”

Fe3O4@nano-cellulose/Cu(ii): a bio-based and magnetically recoverable nano-catalyst for the synthesis of 4H-pyrimido[2,1-b]benzothiazole derivatives

“…1 Among these compounds benzothiazoles and pyrimido [2,1-b]benzothiazoles have attracted considerable interest. Some of these compounds have various biological activities such as antiviral, 2,3 antitumor, [4][5][6] antiinammatory, 7,8 antiallergic, 9 antimicrobial, 10,11 anticonvulsant, 12 antiproliferative 13 and antifungal activities. 14 Pyrimido[2,1-b]benzothiazole derivatives were synthesized through multicomponent reaction between 2-amino benzothiazole, aromatic aldehydes and b-ketoesters.…”