Synthesis and in vitro antimicrobial evaluation of penta-substituted pyridine derivatives bearing the quinoline nucleus

Abstract

A new series of penta-substituted pyridine derivatives bearing the quinoline nucleus have been synthesized by base-catalyzed cyclocondensation reaction through multi-component reaction (MCR) approach. All the synthesized compounds were subjected to in vitro antimicrobial screening against three Gram positive bacteria (Bacillus subtilis, Clostridium tetani, Streptococcus pneumoniae), three Gram negative bacteria (Escherichia coli, Salmonella typhi, Vibrio cholerae), and two fungi (A. fumigatus, Candida albicans). Reviewing the data, majority of the compounds were found to be active against B. subtilis and C. tetani while the most effective compounds 4c and 4e demonstrated MIC 62.5 lg/ml against V. cholerae and E. coli respectively.

Synthesis, characterization and biological activity of some new carbostyril bearing 1H-pyrazole moiety

“…As part of our ongoing research in discovery of new active antimicrobial compounds (Makawana et al, 2011;Ladani et al, 2009aLadani et al, , b, 2010Mungra et al, 2009Mungra et al, , 2011Nirmal et al, 2009Nirmal et al, , 2010Shah et al, 2009a, b;Shah and Patel, 2011;Thakor et al, 2008;Patel, 2009a, b, 2011), in this article, we try to study the influence of carbostyril moiety and pyrazole scaffold combination on the antimicrobial effect. So we report herein the synthesis of some new derivatives of 4-pyrazolyl-N-arylquinoline-2,5-dione 4a-p through MCR approach.…”

(7-Chloroquinolin-4-yl)arylhydrazones: Candida albicansenzymatic repression and cytotoxicity evaluation, Part 2

“…The literature also shows important antifungal properties of hydrazones [25][26][27] . In addition, the quinoline ring is also an important group in medicinal chemistry and has particular utility in antimalarial 28 , antituberculosis 29 , antileishmania 30 and antimicrobial 31 agents.…”

One‐pot Four‐component Synthesis of Highly Functionalized Pyridines Using Nitroketene Dithioacetal as a Source of Methyl Thiolate Under Solvent‐free Condition

“…Pyridine and its derivatives are one of the most important structures in heterocyclic chemistry . Usually molecules that include pyridine and its skeleton exhibits biological and medicinal properties .…”