(7-Chloroquinolin-4-yl)arylhydrazones: Candida albicansenzymatic repression and cytotoxicity evaluation, Part 2

Abstract

These results revealed that select (7-chloroquinolin-4-yl)arylhydrazones may be potential antifungal agents for the control of C. albicans infections.

Antioxidant and Antifungal Activity of Naphthoquinones Dimeric Derived from Lawsone

“…Moreover, industry has stimulated the development of new methods to identify and inhibit these virulence factors with lower doses of antimicrobials, aiming to avoid an increase in antifungal resistance [5].…”

Quinolines and Quinolones as Antibacterial, Antifungal, Anti-virulence, Antiviral and Anti-parasitic Agents

“…The active derivatives showed MIC and MFC values in the range of 25 μg/ml and 50 μg/ml, which was the activity comparable with the fluconazole. Four of these hydrazones potently inhibited enzymatic processes in C. albicans at sub-antifungal concentrations, showing enzymatic repression of phospholipase and aspartyl proteases, which are the most frequent enzymes produced by C. albicans (de Azambuja Carvalho et al 2016). Notably, the compounds exhibited low cytotoxicity against mouse fibroblasts (NIH/3 T3 cell line) at sub-antifungal concentrations.…”

7-Chloroquinolinehydrazones as First-in-Class Anticancer Experimental Drugs in the NCI-60 Screen among Different Investigated Series of Aryl, Quinoline, Pyridine, Benzothiazole and Imidazolehydrazones

“…7-Chloroquinoline hydrazones have been previously developed and successfully tested in vitro for many biological activities [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]. The major part of the studies has been carried out to identify their antimalarial properties [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ].…”

“…The major part of the studies has been carried out to identify their antimalarial properties [ 2 , 3 , 4 , 5 , 6 , 7 , 8 , 9 , 10 ]. In addition, these hydrazones were explored for their anti-leishmanial [ 10 , 11 , 12 , 13 ], anti-tubercular [ 3 , 14 , 15 , 16 , 17 , 18 ], anti-bacterial [ 19 , 20 ], anti-oxidant [ 21 , 22 ], anti-fungal [ 23 , 24 ], anti-viral [ 25 ], anti-inflammatory [ 26 ], anti-prion disease [ 27 ], anti-convulsant [ 28 ], antinociceptive [ 29 ], but also anticancer activities [ 30 , 31 , 32 , 33 ]. Many chemical modulations have been realized on 7-chloroquinoline hydrazones.…”