Synthesis and in vitro antifungal evaluation of benzoimidazolyl-piperazinyl-phenylmethanone derivatives.

Abstract

Benzimidazole and piperazines are the important pharmacophores in the structures of many antifungal compounds. Further, the phenylmethanone are also a unique class of compounds whose antifungal profile is not much exploited. So to exploit their antifungal potential we have selected these three combinations and framed the novel parent structure for our research work. In this study a novel series of benzimidazoles derivatives was synthesized by microwave irradiation and characterized by 1 H NMR, 13 C NMR, Infra Red (IR), and Mass Spectroscopy (MS), and by elemental analysis. The screening of compound for in vitro (turbidimetric method) antifungal activity against C.albicans revealed activity in many of the compounds as comparable to that of ketoconazole.

Organocatalytic Green Approach Towards the Fabrication of Fused Benzo N,N‐containing Heterocycles Facilitated by Ultrasonic Irradiation

“…Benzodiazepines, benzimidazoles, and quinoxalines containing moieties represent a significant class of N ‐heterocycles owing to their varied applications. They are known to exhibit remarkable pharmacological activity such as anti‐microbial , anti‐inflammatory , antidepressants , analgesic , and anticancer activities . Biologically active 1,4‐benzodiazepines have demonstrated considerable utility in the central nervous system drug design , HIV‐1 reverse transcriptase inhibitor.…”

Synthesis, Characterization and Anticonvulsant Potential of 2,5-Disubstituted 1,3,4-Oxadiazole Analogues

“…Albeit older, first generation and newer, second generation antiepileptic medications have showed up in the market, the improvement of novel specialists, especially compounds powerful against complex partial seizures, remains a noteworthy focal point of antiepileptic medicate inquire about epilepsy [6,7]. Nitrogen-containing heterocyclic compounds possess the variety of pharmacological activities , among them 1,3,4-oxadiazoles, benzimidazole and quinoline derivatives are associated with diverse biological activities, such as antibacterial [8][9][10], antimalarial [11][12][13], anti-inflammatory [14][15][16] and antifungal [17][18][19]. Several investigations have also revealed that compounds consisting 1,3,4-oxadiazole, benzimidazole and quinoline pharmacophores in their structure, constitute vary good anticonvulsant potential [20][21][22][23][24][25][26].…”