Synthesis and in vitro anti-HIV activity of N-1,3-benzo[d]thiazol-2-yl-2-(2-oxo-2H-chromen-4-yl)acetamide derivatives using MTT method

A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry

“…On the other hand, compounds (194,195) are showed the potent activity and inhibit Mtb growth at micromolar concentrations, with MIC values of 1.4 and 1.9 mM, respectively. The hydroxamate (196) showed promising activity against T.b.rhodesiense a good activity.…”

“…SAR reveals that, eOH substitution increases the anti-HIV activity and it plays a vital role in hydrogen bonding. While methyl substitution lowersthe biological potential so bulky substitution group does not favorable and this explains that the in activity of compounds [195]. BTApiperazinyl derivative were synthesized and evaluated for the antiviral activity against HIV-1 strain (III B ) and HIV-2 strain (ROD) in MT-4 cells was performed using the MTT assay.…”

Synthesis of Chromen-2-one, Pyrano[3,4-c]chromene and Pyridino[3,4-c]chromene Derivatives as Potent Antimicrobial Agents

“…Some of chromene skeleton are well established as antimicrobial agents such as Novobiocin and Chlorobiocin. [6] Recently, chromene derivatives have great interesting due to their potential application such as anti-HIV, [7] antitubercular, [8] antioxidant, [9] anticancer, [10] cytotoxic agents, [11] antidyslipidemic agent, [12] antileishmanial, [13] anti-inflammatory agents. [14] Diazo compounds showed many valuable medicinal and pharmaceutical activities such as inhibition of RNA, DNA and carcinogenesis, protein synthesis and nitrogen fixation.…”

Microwave assisted synthesis of dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones; synthesis, in vitro antimicrobial and anticancer activities of novel coumarin substituted dihydrobenzo[4,5]imidazo[1,2-a]pyrimidin-4-ones

“…4-Hydroxy coumarin derivatives [14] showed pronounced prolongation of prothrombin time with anticoagulant values similar to that of warfarin. Benzothiazolyl coumarin acetamide derivatives [15] exhibited strong in vitro anti-HIV effect against the wild-type HIV-1 cell line. The in vitro antioxidant activities of 4-schiff bases-7-benzyloxy coumarin derivatives [16] revealed that DPPH and ABTS þ radical scavenging activities were better than that of the commercial antioxidant BHT.…”