A comprehensive review in current developments of benzothiazole-based molecules in medicinal chemistry

Synthesis, properties, antitumor and antibacterial activity of new Pt(II) and Pd(II) complexes with 2,2′-dithiobis(benzothiazole) ligand

“…As reported in 2,6,27 , benzothiazole, Pt(II) and Pd(II) complexes are known to bind DNA. The binding to the DNA of the plasmid pUC19 was monitored by agarose gel electrophoresis.…”

“…BTA analogs offer a high degree of structural diversity that has proven to be useful for the search of new therapeutic agents that exert a wide range of biological activities such as anticancer, antimicrobial, anticonvulsant, antiviral, antitubercular, antimalarial, anthelmintic, analgesic, anti-inflammatory, antidiabetic and fungicidal activity. 2 The BTA is a heterocyclic compound in which benzene ring is fused to 4,5-positions of thiazole ring, is completely planar, and is potentially ambidentate with N and S available to coordination when it is used as ligand in metal ion complexes. The thiazole core is present in many biologically relevant molecules, which are in therapeutic use, such as Sulfathiazole (non-steroidal anti-inflammatory drug), Nitazoxanide (antiprotozoal agent).…”

“…7 The use of bulkier chelating ligands can make them active against tumor. 8 (2) complexes with a derivate of benzothiazole, 2,2 0 -dithiobis(benzothiazole) (DTBTA) ligand and to study their biological activity. Our research group has experience in the synthesis and biological study of mono-and polynuclear Pt(II) complexes 9-11 , so we decided to investigate the antitumor activity of 1 and 2 in vitro against two human cell lines HepG2 and MCF-7.…”

The synthesis, antimicrobial activity studies, and molecular property predictions of novel benzothiazole-2-thione derivatives

“…BTA derivatives have attracted continuing interest due to their diverse biological activities including anticancer, antimicrobial, anticonvulsant, antiviral, antitubercular, antimalarial, antihelminthic, analgesic, antiinflammatory, antidiabetic, and fungicidal activities 2 .…”

“…In their literature review, Keri et.al. 2 and Azam and Suresh 14 found that the pharmacological activity of these systems has been widely investigated and found efficient.…”