Synthesis and immunological evaluation of MUC1 glycopeptide conjugates bearing N-acetyl modified STn derivatives as anticancer vaccines

Xiao, An; Zheng, Xiu-Jing; Song, Chengcheng; Gui, Yue; Huo, Chang‐Xin; Ye, Xin‐Shan

doi:10.1039/c6ob01092j

Cited by 27 publications

(11 citation statements)

References 33 publications

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“…mimetic was also able to activate iNKT cells, when conjugated to a phospholipid carrier, which enabled the mimetic to be presented in the context of the conserved nonpolymorphic MHC class I-like molecules (CD1d) [279]. Modification at the N-acetamido position of the galactose residue of MUC antigens and in the sialic acid containing antigens (e.g., GM3, sTn, sTF) has likewise been widely investigated [280][281][282][283].…”

Section: Glycomimetics In the Discovery Of Anticancer Glycoconjugate Vaccinesmentioning

confidence: 99%

Recent advances on smart glycoconjugate vaccines in infections and cancer

et al. 2021

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Section: Glycomimetics In the Discovery Of Anticancer Glycoconjugate Vaccinesmentioning

confidence: 99%

Recent advances on smart glycoconjugate vaccines in infections and cancer

et al. 2021

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“…Tumor associated carbohydrate antigen (TACA) played a crucial role as a biomarker in the tumorigenesis and development, and it has attracted considerable attention. [ 64‐66 ] The globo‐H is a hexasaccharide containing fucose, glucose, galactosamine and galactose units. Huang and coworkers synthesized globo‐H by utilizing preactivation‐based one‐pot four component [1+2+1+2] glycosylation (Scheme 20).…”

Section: Application Of Preactivation Strategy In the Assembly Of Olimentioning

confidence: 99%

Donor Preactivation‐Based Glycosylation: An Efficient Strategy for Glycan Synthesis

Qin

2021

Chin. J. Chem.

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Carbohydrates have gained a lot of appreciation in the past few decades due to their important roles in numerous biological events. Acquiring a structurally well‐defined carbohydrate compound is essential for the understanding of its functions. Although some innovative methods have been developed for the synthesis of complex oligosaccharides, glycan synthesis is in general still a time‐consuming and difficult work. Herein, we will introduce the preactivation‐based glycosylation strategy, which is an efficient protocol independent of the reactivity of glycosyl donor. This review will focus on summarizing the versatile applications of preactivation strategy in stereoselective glycosylation and one‐pot assembly of biologically important oligosaccharides and even polysaccharides. What is the most favorite and original chemistry developed in your research group? Preactivation‐based one‐pot glycosylation strategy and applications. How do you get into this specific field? Could you please share some experiences with our readers? I got into this field when I was a research associate in 1996. My supervisor, Prof. Chi‐Huey Wong, gave me a research topic for synthesis of oligosaccharide libraries. At that moment, as a beginner, I did not know too much carbohydrate chemistry, just to learn and to do it. The importance and challenge of carbohydrates attracted me. What is the most important personality for scientific research? Curiosity, passion, and creative thinking. How do you supervise your students? In my opinion, before the graduate students start a specific project, their experimental skills need to be well trained. During the period of graduate studies, the enhancement of abilities to analyze problems and to solve problems is very important. The graduate students should always keep an eye on the unusual experimental phenomena. What's your hobbies? Reading history books. What is your favorite journals? The journals publishing the latest research works in chemistry and medical science.

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“…Several STn derivatives with N ‐acetyl modifications were synthesized, they were then incorporated into a MUC1 peptide and were further connected to KLH. The evaluation results of the synthetic vaccine conjugates demonstrated that the carbohydrate antigen modification strategy has the potential to improve immunogenicity of natural MUC1 glycopeptides …”

Section: Advances In Tacas Based Cancer Vaccinesmentioning

confidence: 99%

“…The evaluation results of the synthetic vaccine conjugates demonstrated that the carbohydrate antigen modification strategy has the potential to improve immunogenicity of natural MUC1 glycopeptides. 205…”

Section: Cross-reactivity-based Cancer Vaccinesmentioning

confidence: 99%

Carbohydrate‐based vaccines for oncotherapy

Wei

Wang

2018

Medicinal Research Reviews

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Cancer is still one of the most serious threats to human worldwide. Aberrant patterns of glycosylation on the surface of cancer cells, which are correlated with various cancer development stages, can differentiate the abnormal tissues from the healthy ones. Therefore, tumor-associated carbohydrate antigens (TACAs) represent the desired targets for cancer immunotherapy. However, these carbohydrate antigens may not able to evoke powerful immune response to combat with cancer for their poor immunogenicity and immunotolerance. Different approaches have been developed to address these problems. In this review, we want to summarize the latest advances in TACAs based anticancer vaccines.

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Synthesis and immunological evaluation of MUC1 glycopeptide conjugates bearing N-acetyl modified STn derivatives as anticancer vaccines

Cited by 27 publications

References 33 publications

Recent advances on smart glycoconjugate vaccines in infections and cancer

Recent advances on smart glycoconjugate vaccines in infections and cancer

Donor Preactivation‐Based Glycosylation: An Efficient Strategy for Glycan Synthesis

Carbohydrate‐based vaccines for oncotherapy

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