Synthesis and in vitro antibacterial behavior of curcumin-conjugated gold nanoparticles

Abstract

Owing to the rise in multidrug resistant bacterial diseases and dwindling supply of the newer antibiotics, it is crucial to discover newer compounds or modify current compounds for more effective...

Synthesis of vancomycin functionalized fluorescent gold nanoparticles and selective sensing of mercury (II)

“…The PEI functionalized gold nanoparticles were synthesized per the procedure that was previously reported with slight modification ( Pandey et al, 2023 ). Briefly, 400 μL (10 mM) of hydrogen tetra-chloroauric acid trihydrate (HAuCl 4 .3H 2 O) was placed in a 2 mL glass vial; this step was followed by the addition of an aqueous solution of vancomycin (40 μL, 2 mg/mL stock).…”

“…Amine groups may provide sufficient active sites for functionalization; these features of PEI can facilitate changes to the selectivity of various ions and biomolecules to deliver drugs and genes for breast cancer therapy and to deliver antimicrobial agents ( Li et al, 2015 ; Kumar et al, 2015 ; Tiwari et al, 2020 ; Tiwari et al, 2022 ). Furthermore, Polyethyleneimine has been utilized for synthesizing noble metal nanoparticles ( Tiwari et al, 2020 ; Tiwari et al, 2022 ; Pandey et al, 2023 ) and functionalization with curcumin ( Pandey et al, 2023 ). These studies directed us to consider vancomycin, a potent agent used in the treatment of severe bacterial infections in hospitalized patients, which is a green-fluorescent analog .…”

Selective induction of apoptotic cell death in lung carcinoma cells by curcumin-loaded PEGylated lipid nanoparticles with minimal normal tissue toxicity: in vitro and in vivo toxicity evaluation by oral delivery

“…In vitro and in vivo studies have shown the efficacy of curcumin in inhibiting lung carcinogenesis, tumor cell proliferation and metastasis. [19][20][21][22] However, despite its promising therapeutic effects, the commercial application of curcumin for cancer therapy has not yet realised because upon oral or intravenous/intraperitoneal administration, it is rapidly eliminated from the body due to its poor water solubility (around 400 ng mL À1 at pH 7.4), chemical instability, and consequent degradation in the gastrointestinal tract under physiological conditions followed by non-bioavailability. A series of pHdependent studies has shown that curcumin undergoes rapid decomposition under neutral-basic condition with the formation of trans-6-(4-hydroxy-3-methoxyphenyl)-2,4-dioxo-5hexenal as the main degradation product.…”

A potential strategy against clinical carbapenem-resistant Enterobacteriaceae: antimicrobial activity study of sweetener-decorated gold nanoparticles in vitro and in vivo

“…Among these, gold nanoparticles (Au NPs) find wide-ranging applications due to their minimal toxicity, straightforward surface properties, and the potential for carrying the nanodecoration of existing substances [ 23 ]. Some literature has reported that Au NPs decorated with plant extracts or antibiotics exhibit excellent antimicrobial activity [ 24 – 26 ]. However, these substances might be constrained by extraction difficulties, low solubility, or limited applicability.…”