Synthesis of some condensed pyrrolo-, thieno-, furo-, pyrido-and pyranopteridines as well as isomeric pyrrolo-and thienopyrimido [4,5-c]pyridazines from alkynyl derivatives of 6,8-dimethylpyrimido [4,5-c]pyridazine-5,7(6H,8H)-dione and 1,3-dimethyllumazine is represented.